REFERENCES
1. Tschuschke M, Kocherova I, Bryja A, et al. Inclusion biogenesis, methods of isolation and clinical application of human cellular exosomes. J Clin Med. 2020;9:436.
2. Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750.
3. An T, Qin S, Xu Y, et al. Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis. J Extracell Vesicles. 2015;4:27522.
6. Di H, Zeng E, Zhang P, et al. General approach to engineering extracellular vesicles for biomedical analysis. Anal Chem. 2019;91:12752-9.
7. Fais S, O'Driscoll L, Borras FE, et al. Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine. ACS Nano. 2016;10:3886-99.
8. Zebrowska A, Widlak P, Whiteside T, Pietrowska M. Signaling of tumor-derived sEV impacts melanoma progression. Int J Mol Sci. 2020;21:5066.
9. Keller S, Ridinger J, Rupp AK, Janssen JW, Altevogt P. Body fluid derived exosomes as a novel template for clinical diagnostics. J Transl Med. 2011;9:86.
11. Shang M, Chang C, Pei Y, Guan Y, Chang J, Li H. Potential management of circulating tumor DNA as a biomarker in triple-negative breast cancer. J Cancer. 2018;9:4627-34.
12. Nakashoji A, Matsui A, Nagayama A, Iwata Y, Sasahara M, Murata Y. Clinical predictors of pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer. Oncol Lett. 2017;14:4135-41.
13. Jhan JR, Andrechek ER. Triple-negative breast cancer and the potential for targeted therapy. Pharmacogenomics. 2017;18:1595-609.
14. Green TM, Alpaugh ML, Barsky SH, Rappa G, Lorico A. Breast cancer-derived extracellular vesicles: characterization and contribution to the metastatic phenotype. Biomed Res Int. 2015;2015:634865.
15. Goh CY, Wyse C, Ho M, et al. Exosomes in triple negative breast cancer: garbage disposals or trojan horses? Cancer Lett. 2020;473:90-7.
16. Abhange K, Makler A, Wen Y, et al. Small extracellular vesicles in cancer. Bioact Mater. 2021;6:3705-43.
17. Lopez K, Lai SWT, Lopez Gonzalez EJ, Dávila RG, Shuck SC. Extracellular vesicles: a dive into their role in the tumor microenvironment and cancer progression. Front Cell Dev Biol. 2023;11:1154576.
18. Brena D, Huang MB, Bond V. Extracellular vesicle-mediated transport: reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis. Transl Oncol. 2022;15:101286.
19. Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79:4557-66.
20. Soysal SD, Tzankov A, Muenst SE. Role of the tumor microenvironment in breast cancer. Pathobiology. 2015;82:142-52.
21. Mierke CT. Phenotypic heterogeneity, bidirectionality, universal cues, plasticity, mechanics, and the tumor microenvironment drive cancer metastasis. Biomolecules. 2024;14:184.
22. Poltavets V, Kochetkova M, Pitson SM, Samuel MS. The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity. Front Oncol. 2018;8:431.
23. Imodoye SO, Adedokun KA, Bello IO. From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy. Histochem Cell Biol. 2024;161:299-323.
24. Slepicka PF, Somasundara AVH, Dos Santos CO. The molecular basis of mammary gland development and epithelial differentiation. Semin Cell Dev Biol. 2021;114:93-112.
25. Trappmann B, Gautrot JE, Connelly JT, et al. Extracellular-matrix tethering regulates stem-cell fate. Nat Mater. 2012;11:642-9.
26. Alexander NR, Branch KM, Parekh A, et al. Extracellular matrix rigidity promotes invadopodia activity. Curr Biol. 2008;18:1295-9.
28. Mah EJ, Lefebvre AEYT, McGahey GE, Yee AF, Digman MA. Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility. Sci Rep. 2018;8:17094.
29. Liang R, Song G. Matrix stiffness-driven cancer progression and the targeted therapeutic strategy. Mechanobiology in Medicine. 2023;1:100013.
30. Lee JN, Jiang X, Ryan D, Whitesides GM. Compatibility of mammalian cells on surfaces of poly(dimethylsiloxane). Langmuir. 2004;20:11684-91.
31. Goli-Malekabadi Z, Tafazzoli-Shadpour M, Tamayol A, Seyedjafari E. Time dependency of morphological remodeling of endothelial cells in response to substrate stiffness. Bioimpacts. 2017;7:41-7.
32. Wu B, Liu DA, Guan L, et al. Stiff matrix induces exosome secretion to promote tumour growth. Nat Cell Biol. 2023;25:415-24.
33. Kornilov R, Puhka M, Mannerström B, et al. Efficient ultrafiltration-based protocol to deplete extracellular vesicles from fetal bovine serum. J Extracell Vesicles. 2018;7:1422674.
34. Kim SO, Kim J, Okajima T, Cho NJ. Mechanical properties of paraformaldehyde-treated individual cells investigated by atomic force microscopy and scanning ion conductance microscopy. Nano Converg. 2017;4:5.
35. Grimm KB, Oberleithner H, Fels J. Fixed endothelial cells exhibit physiologically relevant nanomechanics of the cortical actin web. Nanotechnology. 2014;25:215101.
36. Hermanowicz P, Sarna M, Burda K, Gabryś H. AtomicJ: an open source software for analysis of force curves. Rev Sci Instrum. 2014;85:063703.
37. Chen WH, Cheng SJ, Tzen JT, Cheng CM, Lin YW. Probing relevant molecules in modulating the neurite outgrowth of hippocampal neurons on substrates of different stiffness. PLoS One. 2013;8:e83394.
38. Ansardamavandi A, Tafazzoli-Shadpour M, Shokrgozar MA. Behavioral remodeling of normal and cancerous epithelial cell lines with differing invasion potential induced by substrate elastic modulus. Cell Adh Migr. 2018;12:472-88.
39. Azadi S, Tafazzoli-Shadpour M, Soleimani M, Warkiani ME. Modulating cancer cell mechanics and actin cytoskeleton structure by chemical and mechanical stimulations. J Biomed Mater Res A. 2019;107:1569-81.
40. Gil-Redondo JC, Weber A, Zbiral B, Vivanco MD, Toca-Herrera JL. Substrate stiffness modulates the viscoelastic properties of MCF-7 cells. J Mech Behav Biomed Mater. 2022;125:104979.
41. Wala J, Das S. Mapping of biomechanical properties of cell lines on altered matrix stiffness using atomic force microscopy. Biomech Model Mechanobiol. 2020;19:1523-36.
42. Senigagliesi B, Samperi G, Cefarin N, et al. Triple negative breast cancer-derived small extracellular vesicles as modulator of biomechanics in target cells. Nanomedicine. 2022;44:102582.
43. Calzolai L, Gilliland D, Garcìa CP, Rossi F. Separation and characterization of gold nanoparticle mixtures by flow-field-flow fractionation. J Chromatogr A. 2011;1218:4234-9.
44. Vogel R, Savage J, Muzard J, et al. Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: who is up to the challenge? J Extracell Vesicles. 2021;10:e12052.
45. Simon CG Jr, Borgos SE, Calzolai L, et al. Orthogonal and complementary measurements of properties of drug products containing nanomaterials. J Control Release. 2023;354:120-7.
46. Shen J, Zhang D, Zhang F, Gan Y. AFM tip-sample convolution effects for cylinder protrusions. Appl. Surf. Sci. 2017;422:482-91.
47. Bachurski D, Schuldner M, Nguyen PH, et al. Extracellular vesicle measurements with nanoparticle tracking analysis - an accuracy and repeatability comparison between NanoSight NS300 and ZetaView. J Extracell Vesicles. 2019;8:1596016.
48. Gardiner C, Ferreira YJ, Dragovic RA, Redman CW, Sargent IL. Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis. J Extracell Vesicles. 2013:2.
49. Jarzębski M, Bellich B, Białopiotrowicz T, Śliwa T, Kościński J, Cesàro A. Particle tracking analysis in food and hydrocolloids investigations. Food Hydrocolloids. 2017;68:90-101.
50. Filipe V, Hawe A, Jiskoot W. Critical evaluation of nanoparticle tracking analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res. 2010;27:796-810.
51. Khatun Z, Bhat A, Sharma S, Sharma A. Elucidating diversity of exosomes: biophysical and molecular characterization methods. Nanomedicine (Lond). 2016;11:2359-77.
52. Eskelin K, Poranen MM, Oksanen HM. Asymmetrical flow field-flow fractionation on virus and virus-like particle applications. Microorganisms. 2019;7:555.
53. Zhang H, Lyden D. Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization. Nat Protoc. 2019;14:1027-53.
54. Bavli Y, Winkler I, Chen BM, et al. Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs. J Control Release. 2019;306:138-48.
55. El-Tanani M, Rabbani SA, Babiker R, et al. Unraveling the tumor microenvironment: insights into cancer metastasis and therapeutic strategies. Cancer Lett. 2024;591:216894.
57. Liu C, Li M, Dong ZX, et al. Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells. Acta Biomater. 2021;131:326-40.
59. Parsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol. 2010;11:633-43.
60. Iskratsch T, Wolfenson H, Sheetz MP. Appreciating force and shape—the rise of mechanotransduction in cell biology. Nat Rev Mol Cell Biol. 2014;15:825-33.
61. Taufalele PV, Wang W, Simmons AJ, et al. Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment. Acta Biomater. 2023;163:365-77.
62. Lekka M. Discrimination between normal and cancerous cells using AFM. Bionanoscience. 2016;6:65-80.
63. Senigagliesi B, Bedolla DE, Birarda G, et al. Subcellular elements responsive to the biomechanical activity of triple-negative breast cancer-derived small extracellular vesicles. Biomol Concepts. 2022;13:322-33.
64. Liu T, Zhou L, Li D, Andl T, Zhang Y. Cancer-associated fibroblasts build and secure the tumor microenvironment. Front Cell Dev Biol. 2019;7:60.
65. Webber JP, Spary LK, Sanders AJ, et al. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene. 2015;34:290-302.
66. Jiang T, Zhao J, Yu S, et al. Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels. Biomaterials. 2019;188:130-43.
67. Abidine Y, Constantinescu A, Laurent VM, et al. Mechanosensitivity of cancer cells in contact with soft substrates using AFM. Biophys J. 2018;114:1165-75.
68. Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science. 2005;310:1139-43.
69. Sedgwick AE, Clancy JW, Olivia Balmert M, D'Souza-Schorey C. Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion. Sci Rep. 2015;5:14748.
70. Yousafzai MS, Coceano G, Bonin S, Niemela J, Scoles G, Cojoc D. Investigating the effect of cell substrate on cancer cell stiffness by optical tweezers. J Biomech. 2017;60:266-9.
71. Kristal-muscal R, Dvir L, Weihs D. Metastatic cancer cells tenaciously indent impenetrable, soft substrates. New J Phys. 2013;15:035022.
72. Yamaguchi N, Knaut H. Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo. Development. 2022;149:dev200647.
73. Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Signal. 2021;19:47.
74. Ge H, Tian M, Pei Q, Tan F, Pei H. Extracellular matrix stiffness: new areas affecting cell metabolism. Front Oncol. 2021;11:631991.
