REFERENCES

1. Luan DD, Korman MH, Jakubczak JL, Eickbush TH. Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition. Cell 1993;72:595-605.

2. De Cecco M, Ito T, Petrashen AP, et al. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature 2019;566:73-8.

3. Della Valle F, Reddy P, Yamamoto M, et al. LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes. Sci Transl Med 2022;14:eabl6057.

4. Liu X, Liu Z, Wu Z, et al. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell 2023;186:287-304.e26.

5. Johnson WE. Origins and evolutionary consequences of ancient endogenous retroviruses. Nat Rev Microbiol 2019;17:355-70.

6. Blikstad V, Benachenhou F, Sperber GO, Blomberg J. Evolution of human endogenous retroviral sequences: a conceptual account. Cell Mol Life Sci 2008;65:3348-65.

7. Marchi E, Kanapin A, Magiorkinis G, Belshaw R. Unfixed endogenous retroviral insertions in the human population. J Virol 2014;88:9529-37.

8. Subramanian RP, Wildschutte JH, Russo C, Coffin JM. Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses. Retrovirology 2011;8:90.

9. Stoye JP. Studies of endogenous retroviruses reveal a continuing evolutionary saga. Nat Rev Microbiol 2012;10:395-406.

10. Doucet-O'Hare TT, DiSanza BL, DeMarino C, et al. SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression. Sci Rep 2021;11:12893.

11. Wang T, Medynets M, Johnson KR, et al. Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway. Proc Natl Acad Sci U S A 2020;117:17842-53.

12. Steiner JP, Bachani M, Malik N, et al. Human endogenous retrovirus k envelope in spinal fluid of amyotrophic lateral sclerosis is toxic. Ann Neurol 2022;92:545-61.

13. Shah AH, Rivas SR, Doucet-O'Hare TT, et al. Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma. J Clin Invest 2023;133:e167929.

14. Grow EJ, Flynn RA, Chavez SL, et al. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Nature 2015;522:221-5.

15. Pastuzyn ED, Day CE, Kearns RB, et al. The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer. Cell 2018;172:275-88.e18.

16. Frendo JL, Olivier D, Cheynet V, et al. Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol 2003;23:3566-74.

17. Mangeney M, Renard M, Schlecht-Louf G, et al. Placental syncytins: genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins. Proc Natl Acad Sci U S A 2007;104:20534-9.

18. Knerr I, Huppertz B, Weigel C, et al. Endogenous retroviral syncytin: compilation of experimental research on syncytin and its possible role in normal and disturbed human placentogenesis. Mol Hum Reprod 2004;10:581-8.

19. Bolze P, Mommert M, Mallet F. Contribution of syncytins and other endogenous retroviral envelopes to human placenta pathologies. Prog Mol Biol Transl Sci 2017;145:111-62.

20. Cornelis G, Vernochet C, Carradec Q, et al. Retroviral envelope gene captures and syncytin exaptation for placentation in marsupials. Proc Natl Acad Sci U S A 2015;112:E487-96.

21. Frendo JL, Vidaud M, Guibourdenche J, et al. Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down's syndrome. J Clin Endocrinol Metab 2000;85:3700-7.

22. Massin N, Frendo JL, Guibourdenche J, et al. Defect of syncytiotrophoblast formation and human chorionic gonadotropin expression in Down's syndrome. Placenta 2001;22 Suppl A:S93-7.

23. Vargas A, Toufaily C, LeBellego F, Rassart E, Lafond J, Barbeau B. Reduced expression of both syncytin 1 and syncytin 2 correlates with severity of preeclampsia. Reprod Sci 2011;18:1085-91.

24. Lee X, Keith JC Jr, Stumm N, et al. Downregulation of placental syncytin expression and abnormal protein localization in pre-eclampsia. Placenta 2001;22:808-12.

25. Soygur B, Sati L, Demir R. Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta. Histol Histopathol 2016;31:1037-47.

26. Shah AH, Govindarajan V, Doucet-O'Hare TT, et al. Differential expression of an endogenous retroviral element [HERV-K(HML-6)] is associated with reduced survival in glioblastoma patients. Sci Rep 2022;12:6902.

27. Liu S, Heumuller SE, Hossinger A, et al. Reactivated endogenous retroviruses promote protein aggregate spreading. Nat Commun 2023;14:5034.

28. Vargas A, Zhou S, Éthier-Chiasson M, et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB J 2014;28:3703-19.

29. Contreras-Galindo R, Kaplan MH, Dube D, et al. Human endogenous retrovirus type K (HERV-K) particles package and transmit HERV-K-related sequences. J Virol 2015;89:7187-201.

30. Lötvall J, Hill AF, Hochberg F, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the international society for extracellular vesicles. J Extracell Vesicles 2014;3:26913.

31. Li Y, Chen Y, Zhang N, Fan D. Human endogenous retrovirus K (HERV-K) env in neuronal extracellular vesicles: a new biomarker of motor neuron disease. Amyotroph Lateral Scler Frontotemporal Degener 2022;23:100-7.

32. Record M. Intercellular communication by exosomes in placenta: a possible role in cell fusion? Placenta 2014;35:297-302.

33. Ovadya Y, Landsberger T, Leins H, et al. Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun 2018;9:5435.

34. Yin Y, Chen H, Wang Y, Zhang L, Wang X. Roles of extracellular vesicles in the aging microenvironment and age-related diseases. J Extracell Vesicles 2021;10:e12154.

35. Wood JG, Helfand SL. Chromatin structure and transposable elements in organismal aging. Front Genet 2013;4:274.

36. Manghera M, Douville RN. Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors? Retrovirology 2013;10:16.

37. Levine KS, Leonard HL, Blauwendraat C, et al. Virus exposure and neurodegenerative disease risk across national biobanks. Neuron 2023;111:1086-93.e2.

38. Franceschi C, Bonafè M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244-54.

39. O'Carroll IP, Fan L, Kroupa T, et al. Structural mimicry drives HIV-1 Rev-mediated HERV-K expression. J Mol Biol 2020;432:166711.

40. Petrone V, Fanelli M, Giudice M, et al. Expression profile of HERVs and inflammatory mediators detected in nasal mucosa as a predictive biomarker of COVID-19 severity. Front Microbiol 2023;14:1155624.

41. Wang D, Gomes MT, Mo Y, et al. Human endogenous retrovirus, SARS-CoV-2, and HIV promote PAH via inflammation and growth stimulation. Int J Mol Sci 2023;24:7472.

42. Temerozo JR, Fintelman-Rodrigues N, Dos Santos MC, et al. Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology. Microbiome 2022;10:65.

43. Wildschutte JH, Williams ZH, Montesion M, Subramanian RP, Kidd JM, Coffin JM. Discovery of unfixed endogenous retrovirus insertions in diverse human populations. Proc Natl Acad Sci U S A 2016;113:E2326-34.

44. Burn A, Roy F, Freeman M, Coffin JM. Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues. PLoS Biol 2022;20:e3001826.

45. Büscher K, Hahn S, Hofmann M, et al. Expression of the human endogenous retrovirus-K transmembrane envelope, Rec and Np9 proteins in melanomas and melanoma cell lines. Melanoma Res 2006;16:223-34.

46. Temin HM, Mizutani S. Viral RNA-dependent DNA Polymerase: RNA-dependent DNA polymerase in virions of rous sarcoma virus. Nature 1970;226:1211-3.

47. Baltimore D. Viral RNA-dependent DNA Polymerase: RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature 1970;226:1209-11.

48. Berkhout B, Jebbink M, Zsíros J. Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus. J Virol 1999;73:2365-75.

49. Ono M, Yasunaga T, Miyata T, Ushikubo H. Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome. J Virol 1986;60:589-98.

50. Cortopassi G, Liu Y. Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology. Mutat Res 1995;338:151-9.

51. Seth RB, Sun L, Ea CK, Chen ZJ. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 2005;122:669-82.

52. Schoggins JW, MacDuff DA, Imanaka N, et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2014;505:691-5.

53. Horn MD, MacLean AG. Extracellular vesicles as a means of viral immune evasion, CNS invasion, and glia-induced neurodegeneration. Front Cell Neurosci 2021;15:695899.

54. Kritsilis M, V Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D. Ageing, cellular senescence and neurodegenerative disease. Int J Mol Sci 2018;19:2937.

55. Ruan Z, Pathak D, Venkatesan Kalavai S, et al. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain 2021;144:288-309.

56. Herman S, Djaldetti R, Mollenhauer B, Offen D. CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology. Brain 2023;146:209-24.

57. Komurian-Pradel F, Paranhos-Baccala G, Bedin F, et al. Molecular cloning and characterization of MSRV-related sequences associated with retrovirus-like particles. Virology 1999;260:1-9.

58. Sun W, Samimi H, Gamez M, Zare H, Frost B. Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci 2018;21:1038-48.

59. Hardy MP, Audemard É, Migneault F, et al. Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs. Sci Rep 2019;9:7203.

60. Bowers EC, Motta A, Knox K, McKay BS, Ramos KS. LINE-1 cargo and reverse transcriptase activity profiles in extracellular vesicles from lung cancer cells and human plasma. Int J Mol Sci 2022;23:3461.

61. Keswani RK, Pozdol IM, Pack DW. Design of hybrid lipid/retroviral-like particle gene delivery vectors. Mol Pharm 2013;10:1725-35.

62. Dang DD, Rosenblum JS, Shah AH, Zhuang Z, Doucet-O'Hare TT. Epigenetic regulation in primary CNS tumors: an opportunity to bridge old and new WHO classifications. Cancers 2023;15:2511.

63. Zhang J, Ohta T, Maruyama A, et al. BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol Cell Biol 2006;26:7942-52.

64. Doucet-O'Hare TT, Rosenblum JS, Shah AH, Gilbert MR, Zhuang Z. Endogenous retroviral elements in human development and central nervous system embryonal tumors. J Pers Med 2021;11:1332.

65. Li W, Lee MH, Henderson L, et al. Human endogenous retrovirus-K contributes to motor neuron disease. Sci Transl Med 2015;7:307ra153.

Extracellular Vesicles and Circulating Nucleic Acids
ISSN 2767-6641 (Online)
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