fig6

Figure 6. Tau mutations and tau protein isoforms. (A) Tau mutations. Tau missense and deletion mutations located in six tau isoforms (listed in legend for tau isoforms) are illustrated. The mutations are mapped for the representative 2N4R isoform; (B) Tau protein isoforms. Six CNS tau isoforms are illustrated with respect to the N1 and N2 domains at the N-terminal regions with the four R1, R2, R3, and R4 domains of the MTBR. The six tau isoforms are shown as 2N4R, 2N3R, 1N4R, 1N3R, 0N4R, and 0N3R. MTBR: microtubule-binding domain region.