fig3
Figure 3. Proteins that are downregulated, upregulated, or of similar levels in mTau compared to mPS1 EVs. (A) Heatmap with hierarchical clustering illustrates downregulated and upregulated proteins in mTau compared to mPS1 EVs. The heatmap shows log2(mTau/mPS1) ratios that were significant (P < 0.05); (B) Downregulated and upregulated proteins in mTau vs. mPS1 EVs. Protein components found to be significantly downregulated or upregulated in mTau compared to mPS1 proteomes are listed by gene and protein names. Significance is defined as P < 0.05 for log2 ratios of (mTau/mPS1) quantitation of proteins. Functions of these proteins are provided in Supplementary Table 4; (C) Proteins at similar levels in mTau and mPS1 EVs. Proteins present in both mTau and mPS1 EVs of similar levels are listed by gene names. EVs: extracellular vesicles.
