fig8

Figure 8. Different biological activities of DCV-derived soluble CPE and sEV-CPE. Soluble CPE secreted from high metastatic HCCH cells inds HTR1E receptors on recipient HCCH cells and activates ERK-BCL2 signaling pathway to promote survival under hypoxic stress. HCCH-derived sEVs that contain CPE are taken up by recipient low metastatic HCCL cells to enhance proliferation and invasion. HCCH: hepatocellular carcinoma; DCV: dense core vesicles; sEVs: small extracellular vesicles; CPE: carboxypeptidase E.