fig3

Figure 3. Combined index of AFP and Plasma CD147⁺ sEVs improves diagnostic efficiency for HCC. (A) The diagnostic values of CD147⁺ sEVs in distinguishing HCC patients from HD; (B) The diagnostic values of CD147⁺ sEVs for distinguishing AFP-negative HCC patients from HD; (C) The diagnostic values of CD147⁺ sEVs in distinguishing HCC patients with tumor size less than 5 cm from HD; (D) The diagnostic values of CD147⁺ sEVs in distinguishing HCC patients with tumor size greater than or equal to 5 cm from HD; (E-H): (E) The diagnostic values of CD147⁺ sEVs in distinguishing HCC patients with HCC at BCLC-A; (F)BCLC-B; (G) BCLC-C; (H)BCLC-D stage from HD; (I) The diagnostic values of CD147⁺ sEVs in distinguishing HCC patients from LC patients. HCC: hepatocellular carcinoma; CD147⁺ sEVs: CD147-positive small extracellular vesicles; HD: healthy donors; LC: liver cirrhosis; BCLC: barcelona clinical liver cancer; AFP: Alpha-fetoprotein.