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From: Hepatocellular carcinoma cell-derived small extracellular vesicle-associated CD147 serves as a diagnostic marker and promotes endothelial cell angiogenesis via the PI3K/Akt pathway

Hepatocellular carcinoma cell-derived small extracellular vesicle-associated CD147 serves as a diagnostic marker and promotes endothelial cell angiogenesis via the PI3K/Akt pathway

Figure 1. High-level expression of CD147 is associated with liver tumorigenesis. (A) The expression levels (FPKM, log₂) of CD147 in tumor tissues (n = 50) of clinical liver cancer and normal tissue samples from TCGA; (B) The expression (TPM, log₂) of CD147 in a cohort of clinical liver cancer (n = 369) and normal (n = 50) samples from TCGA; (C) Kaplan Meier survival analyses for OS; (D) The expression of CD147 in HCC tumor and tumor-adjacent samples (n = 22) was analyzed by immunohistochemistry. Representative images are shown. Scale bar: 100 μm. TCGA: the cancer genome atlas; OS: overall survival; HCC: hepatocellular carcinoma.