REFERENCES
1. Giamarellos-Bourboulis, E. J. et al. The pathophysiology of sepsis and precision-medicine-based immunotherapy. Nat. Immunol. 25, 19-28 (2024).
2. Kostallari, E. ; Schwabe, R. F.; Guillot, A. Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells. Cell. Mol. Immunol. 22, 1205-25 (2025).
4. Chen, L. et al. Hepatic Smad4 mediates antibacterial defense via macrophage recruitment. Element 1, 9 (2026).
5. Lerner, L. ; Henriksen, M. A.; Zhang, X.; Darnell, J. E., Jr. STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Genes Dev. 17, 2564-77 (2003).
6. Wang, R. H. et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell metab. 2, 399-409 (2005).
7. Song, C. Z.; Tian, X.; Gelehrter, T. D. Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3. Proc. Natl. Acad. Sci. U S A. 96, 11776-81 (1999).
8. Wang, G. et al. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene 35, 4388-98 (2016).
9. Nakashima, K. et al. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284, 479-82 (1999).
10. Lörchner, H. et al. Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart. Nat. Med. 21, 353-62 (2015).
11. Zhang, S. et al. A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma. Neuron 114, 3381-99.e11 (2026).
12. Martins, R. et al. Disease tolerance as an inherent component of immunity. Annu. Rev. Immunol. 37, 405-37 (2019).
13. Zhang, S. ; Wang, Z.; Min, J.; Wang, F.; Chen, L. Rewiring brain iron biology: development, plasticity and disease. Element 1, 6 (2026).
14. De Domenico, I. et al. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J. Clin. Invest. 120, 2395-405 (2010).
