REFERENCES

1. Keane, M. et al. Insights into the evolution of longevity from the bowhead whale genome. Cell Rep. 10, 112-22 (2015).

2. Firsanov, D. et al. Evidence for improved DNA repair in the long-lived bowhead whale. Nature 648, 717-25 (2025).

3. López-Otín, C.; Blasco, M. A.; Partridge, L.; Serrano, M.; Kroemer, G. Hallmarks of aging: an expanding universe. Cell 186, 243-78 (2023).

4. Tian, X. et al. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature 499, 346-9 (2013).

5. Chen, Y. et al. A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging. Science 390, eadp5056 (2025).

6. Abegglen, L. M. et al. Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. JAMA 314, 1850-60 (2015).

7. Vazquez, J. M.; Sulak, M.; Chigurupati, S.; Lynch, V. J. A zombie LIF gene in elephants is upregulated by TP53 to induce apoptosis in response to DNA damage. Cell Rep. 24, 1765-76 (2018).

8. Levine, A. J. p53: 800 million years of evolution and 40 years of discovery. Nat. Rev. Cancer 20, 471-80 (2020).

9. Yang, Y. et al. Metformin decelerates aging clock in male monkeys. Cell 187, 6358-78.e29 (2024).

10. Glen, C. G. et al. Aging dynamics in captive sea turtles reflect conserved life-history patterns across the testudine phylogeny. Commun. Biol. 8, 1297 (2025).

11. Muradian, K. K.; Fraifeld, V. E. Metazoans who live longer than jeanne calment. In: Rejuvenation and Longevity; Healthy Ageing and Longevity, Vol. 20; Springer, Cham, 2024.

12. Nurk, S. et al. The complete sequence of a human genome. Science 376, 44-53 (2022).

13. Tabula Muris Consortium. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature 583, 590-5 (2020).

14. Ma, S. et al. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging. Cell 187, 7025-44.e34 (2024).

15. Horvath, S.; Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371-84 (2018).

16. D. et al. The FAIR Guiding Principles for scientific data management and stewardship. Sci. Data 3, 160018 (2016).

17. Hasin, Y.; Seldin, M.; Lusis, A. Multi-omics approaches to disease. Genome Biol. 18, 83 (2017).

18. Lu, A. T. et al. Universal DNA methylation age across mammalian tissues. Nat. Aging 3, 1144-66 (2023).

19. Pan, Y. et al. ElixirSeeker: a machine learning framework utilizing fusion molecular fingerprints for the discovery of lifespan-extending compounds. Aging Cell 24, e70116 (2025).

20. Li, H. et al. Inferring transcription factor regulatory networks from single-cell ATAC-seq data based on graph neural networks. Nat. Mach. Intell. 4, 389-400 (2022).

21. Munson, B. P. et al. De novo generation of multi-target compounds using deep generative chemistry. Nat. Commun. 15, 3636 (2024).

22. He, Y. et al. Generalized biological foundation model with unified nucleic acid and protein language. Nat. Mach. Intell. 7, 942-53 (2025).