REFERENCES

1. Dixon, S. J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060-72 (2012).

2. Dai, E. et al. A guideline on the molecular ecosystem regulating ferroptosis. Nat. Cell Biol. 26, 1447-57 (2024).

3. Brown, A. R.; Hirschhorn, T.; Stockwell, B. R. Ferroptosis-disease perils and therapeutic promise. Science 386, 848-9 (2024).

4. Ramos, S.; Hartenian, E.; Santos, J. C.; Walch, P.; Broz, P. NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. EMBO J 43,1164-86 (2024).

5. Hirata, Y. et al. Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis. Curr. Biol. 33,1282-94.e5 (2023).

6. Zhuang, X. et al. Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis. Nature 637, 184-94 (2025).

7. Chen, Y. et al. Oxidative stress induces mitochondrial iron overload and ferroptotic cell death. Sci. Rep. 13, 15515 (2023).

8. Cañeque, T. et al. Activation of lysosomal iron triggers ferroptosis in cancer. Nature 642, 492-500 (2025).

9. Yang, W. S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317-31 (2014).

10. Lorenz, S. M. et al. A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis. Online ahead of print. Cell S0092-8674(25)01310-8 (2025).

11. Hu, Y. et al. Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression. Mol. Cell 85, 4602-20.e9 (2025).

12. Yang, J. S. et al. ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1. Cell 188, 2569-85.e20 (2025).

13. Palma, M. et al. Lymph node environment drives FSP1 targetability in metastasizing melanoma. Online ahead of print. Nature (2025).[PMID41193799 DOI:10.1038/s41586-025-09709-1].

14. Wu, K. et al. Targeting FSP1 triggers ferroptosis in lung cancer. Online ahead of print. Nature (2025).

15. Swanda, R. V. et al. Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response. Mol. Cell 83, 3347-59.e9 (2023).

16. Park, S. Y. et al. Clinical evaluation of (4S)-4-(3-[¹⁸F]Fluoropropyl)-L-glutamate (¹⁸F-FSPG) for PET/CT imaging in patients with newly diagnosed and recurrent prostate cancer. Clin. Cancer Res. 26, 5380-7 (2020).

17. Liu, L. et al. Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. Available on February 19, 2026. Cell 189, 1-18 (2026).

18. Morgan, P. K. et al. A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility. Nat. Cell Biol. 26, 645-59 (2024).

19. Belaidi, A. A. et al. Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy. Mol. Psychiatry 29, 211-20 (2024).

20. Li, J. et al. Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. Sci. Transl. Med. 15, eadg3049 (2023).