fig6

Figure 6. The combination of PTT and chemotherapy. (A) Preparation and antitumor mechanism of biomimetic layered MoO_x@M-SN38 nanosheets. (Reproduced with permission^[105]. Copyright 2023, Elsevier); (B) The fabrication and the multifunctions of PEG@WO_2.9@DOX nanosheets. (Reproduced with permission^[50]. Copyright 2021, Elsevier). PTT: Photothermal therapy; PEG: polyethylene glycol; DOX: doxorubicin; NIR: near-infrared; SN-38: 7-ethyl-10-hydroxycamptothecin; MoO_x@M-SN38: cell membrane wrapped MoO_x loaded with SN38; ICD: immunogenic cell death; DAMPs: danger associated molecular patterns; DCs: dendritic cells; STING: stimulator of interferon genes; cGAS: cyclic guanosine monophosphate-adenosine monophosphate synthase; cGAMP: 2’3’ cyclic GMP (guanosine monophosphate)-AMP (adenosine monophosphate); P-STING: phosphorylated-STING; IFN: interferon; CTLs: cytotoxic T cells; Ths: helper T cells; M2: M2 macrophages; Tregs: regulatory T cells; NSs: nanosheets; PEG@WO_2.9@DOX: PEG-coated WO_2.9 loaded with DOX; PA: photoacoustic; CT: computerized tomography; FL: fluorescence.