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Figure 2. Shared genetic loci between AD and migraine phenotypes identified by CPASSOC. (A-C) Manhattan plots displaying the cross-trait genome-wide association signals for (A) AD and overall migraine, (B) AD and MA, and (C) AD and MO. The y-axis represents the -log10-transformed P-values derived from the CPASSOC analysis across the autosomes. Lead SNPs for the identified loci are annotated. Black text indicates significant shared loci, defined by a stringent cross-trait genome-wide significance threshold (P_CPASSOC < 5 × 10^-8) and a strict single-trait threshold of P < 5 × 10^-3 for both underlying phenotypes. Grey text denotes suggestive shared loci, defined by the cross-trait genome-wide significance threshold (P_CPASSOC < 5 × 10^-8) and a single-trait threshold of P < 0.05 for both underlying phenotypes. Red dots indicate SNPs surpassing the cross-trait genome-wide significance threshold in the respective CPASSOC analysis. AD: Alzheimer’s disease; MA: migraine with aura; MO: migraine without aura; SNPs: single-nucleotide polymorphisms.