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Figure 3. Shared transcriptional modules between mDA neurons and the ENS. (A) Venn diagram illustrates the overlap of gene sets derived from adult human DEG from mDA neurons (PD vs. control), developing human mDA neurons, adult human ENS and developing human ENS. KEGG pathway enrichment was conducted separately for genes shared only in the adult stage, only in the developmental stage, and those shared across both stages; (B) Venn diagram illustrates the overlap of gene sets derived from adult mouse mDA neurons, developing mouse mDA neurons, adult mouse ENS and developing mouse ENS. KEGG pathway enrichment was conducted separately for genes shared only in the adult stage, only in the developmental stage, and those shared across both stages; (C) Venn diagram illustrates the overlap of gene sets derived from human mDA vs. ENS and mouse mDA vs. ENS. KEGG pathway enrichment was also conducted for common gene set. The top6 enriched pathways are visualized based on signal strength, gene count, and FDR. mDA: Midbrain dopaminergic; ENS: enteric nervous system; DEG: differentially expressed gene; PD: Parkinson’s disease; KEGG: Kyoto Encyclopedia of Genes and Genomes; FDR: false discovery rate.