fig2

Figure 2. Overlapping gene networks between mDA neurons and dorsal root ganglion sensory neurons (mDA and DRG). (A) Venn diagram illustrates the overlap of gene sets derived from adult human DEG from mDA neurons (PD vs. control), developing human mDA neurons, adult human DRG and developing human DRG. KEGG pathway enrichment was conducted separately for genes shared only in the adult stage, only in the developmental stage, and those shared across both stages; (B) Venn diagram illustrates the overlap of gene sets derived from adult mouse mDA neurons, developing mouse mDA neurons, adult mouse DRG and developing mouse DRG. KEGG pathway enrichment was conducted separately for genes shared only in the adult stage, only in the developmental stage, and those shared across both stages; (C) Venn diagram illustrates the overlap of gene sets derived from human mDA vs. DRG and mouse mDA vs. DRG. KEGG pathway enrichment was also conducted for common gene set. The top6 enriched pathways are visualized based on signal strength, gene count, and FDR. mDA: Midbrain dopaminergic; DRG: dorsal root ganglia; DEG: differentially expressed gene; PD: Parkinson’s disease; KEGG: Kyoto Encyclopedia of Genes and Genomes; FDR: false discovery rate.