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Figure 1. Integrated analysis of shared molecular programs between mDA neurons and the OB. (A) Venn diagram illustrates the overlap of gene sets derived from adult human DEG from mDA neurons (PD vs. control), developing human mDA neurons, and DEGs from OB samples (PD vs. control). KEGG pathway enrichment was conducted separately for genes shared only in the adult stage, only in the developmental stage, and those shared across both stages; (B) Venn diagram illustrates the overlap of gene sets derived from adult mouse mDA neurons, developing mouse mDA neurons, adult mouse OB and developing mouse OB. KEGG pathway enrichment was conducted separately for genes shared only in the adult stage, only in the developmental stage, and those shared across both stages; (C) Venn diagram illustrates the overlap of gene sets derived from human mDA vs. OB and mouse mDA vs. OB. KEGG pathway enrichment was also conducted for common gene set. The top6 enriched pathways are visualized based on signal strength, gene count, and FDR. Human adult OB transcriptomic data with sufficient quality were not available and are therefore not included in this comparison. mDA: Midbrain dopaminergic; OB: olfactory bulb; DEG: differentially expressed gene; PD: Parkinson’s disease; KEGG: Kyoto Encyclopedia of Genes and Genomes; FDR: false discovery rate.