fig11

Figure 11. LFAST for the de novo discovery of COF-2000. (A) The synthesis scheme of COF-2000 with the optimized crystallization condition; (B) 96-condition screening of solvent and catalyst compositions displayed as pie charts in a well plate layout (A1-H12), where slice areas indicate the volumetric fraction; (C) Heat map of the CI for the fourth-batch screening; deeper red indicates higher crystallinity, and black squares indicate noncrystalline products; (D) Calculated and representative experimental PXRD patterns from the best condition in each screening batch; (E) Best-in-batch and plate-average CI values from the first to fourth screening batches. Adapted with permission from reference^[20] Copyright © 2026 American Chemical Society. LFAST: LLM for Accelerated Synthesis Technique; COF: covalent organic framework; PXRD: powder X-ray diffraction; CI: crystallinity index; Tp: 1,3,5-triformylphloroglucinol; TABTA: tris(4-aminophenyl)benzene-1,3,5-tricarboxamide; p-TsOH: p-toluenesulfonic acid; n-BuOH: n-butanol; BzCN: benzonitrile; Cu Kα: copper K-alpha radiation.