fig10

Figure 10. Representative stage-3 closed-loop experimental workflow for AI-agent-driven materials discovery. The framework integrates literature knowledge extraction, experimental-condition generation, automated reaction setup, crystallization, and high-throughput characterization into an iterative feedback loop that continuously updates subsequent decisions. Reprinted with permission from reference^[20] Copyright © 2026 American Chemical Society. LFAST: LLM for Accelerated Synthesis Technique; COF: covalent organic framework; PXRD: powder X-ray diffraction.