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Original Article  |  Open Access  |  22 Apr 2021

Stapler vs. hand-sewn intrathoracic esophagogastric anastomosis: which anastomotic method renders better results?

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Mini-invasive Surg 2021;5:19.
10.20517/2574-1225.2021.07 |  © The Author(s) 2021.
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Aim: We investigated the impact of the anastomotic method in the frame of open abdominothoracic esophageal resection (hand-sewn vs. stapler anastomosis) in patients with carcinoma submitted to surgery in the University Clinic of Saarland over a 14-year period.

Methods: In total, 176 patients underwent an abdominothoracic resection with intrathoracic anastomosis and conventional gastric conduit formation; two groups of patients were analyzed: end-to-end, hand-sewn anastomosis (Group 1) and end-to-side, circular stapler anastomosis (Group 2). Both groups were compared regarding anastomotic leaks and strictures, postoperative morbidity, 90-day mortality and survival.

Results: The rates of anastomotic leak and stricture in the stapler group were reduced in comparison to hand-sewn group, however without reaching statistical significance (8% vs. 13.5%, P = 0.22, and 6% vs. 13.5%, P = 0.1, respectively). In contrast, the rates of redo surgery (34.1% vs. 8%, P = 0.001) and 90-day mortality (11.9% vs. 2%, P = 0.02) were significantly higher in the hand-sewn anastomosis group.

Conclusion: The management of anastomotic leak (stent insertion vs. reoperation) combined with the use of stapler to perform intrathoracic esophagogastric anastomosis improved the postoperative outcome after abdominothoracic esophageal resection.


Esophagogastric anastomosis, circular stapler, Clavien-Dindo classification, anastomotic leak, gastric tube, esophagectomy, esophageal resection, Ivor-Lewis esophagectomy


Esophageal cancer is a severe disease with poor prognosis. The reconstruction of alimentary tract after esophageal resection remains a challenge, with anastomotic leak being a main reason for major postoperative morbidity after abdominothoracic esophagectomy. The incidence of anastomotic leak varies from 0% to 24%[1-4], leading to higher rates of postoperative morbidity and mortality[5]. Various factors have been suggested to promote anastomotic leak, including patient-related characteristics[6,7], perioperative factors[8] and surgical technique (undo tension on the anastomosis, technical failures, adequacy of blood supply of both organs at the connection site[9] and location of the esophagogastric anastomosis[10]). Controversy remains about the optimal location of esophagogastric anastomosis (intrathoracic vs. cervical). Intrathoracic esophagogastric anastomosis has been associated with lower anastomotic leak rate, lower rate of recurrent nerve paresis and shorter hospital stay than a cervical anastomosis[6,10,11]. However, three randomized controlled trials could not show statistical difference in anastomotic leak rate between intrathoracic and cervical location[12-14]. Advantages of cervical anastomosis include wider oncologic resection margin and less devastating complications compared with intrathoracic anastomosis (risk of mediastinitis and esophagobronchial fistula). A potential solution to manage the challenge of intrathoracic esophagogastric anastomosis could be the use of a stapler device to perform the anastomosis; therefore, we focused on this topic of paramount importance in the present study. Since the first use of stapler anastomosis in 1979[15], there have been several reports supporting its use in order to reduce the rate of anastomotic leak[16,17]. Further technical variations, including the use of linear stapler to perform semi-mechanical intrathoracic anastomosis, have also been suggested to reduce postoperative anastomotic leak rate[18]. We investigated the impact of anastomotic method (hand-sewn vs. circular stapler) on anastomotic leak rate in patients with esophageal carcinoma submitted to intrathoracic esophagogastric anastomosis in the University Clinic of Saarland during a 14-year period.


We performed a retrospective, non-randomized study to investigate which anastomotic method rendered better results. Our study population consisted of 176 patients with esophageal carcinoma, with intrathoracic anastomosis after abdominothoracic resection. We performed an Ivor-Lewis abdominothoracic esophageal resection, consisting of a median laparotomy, mobilization of the stomach and preparation of a conventional gastric tube. Simultaneous cholecystectomy was routinely performed[19]. The gastric conduits were performed conventionally[20] (three patients submitted to fundus rotation gastroplasty to achieve longer gastric conduit and better blood supply[9] were excluded). For conventional tube formation, the lesser curvature with the vessel arcade was resected with linear stapler[21]. The right gastric and gastroepiploic vessels provide the blood supply of the gastric conduit. A right anterolateral thoracotomy was performed, and the esophageal resection was performed in the level of azygos vein. D2 lymphadenectomy was routinely performed. Patients were divided into two groups: Group 1 received hand-sewn, double row, end-to-end anastomosis using 4-0 PDS and 5-0 PDS stitches and Group 2 received single row end-to-side, stapler anastomosis using a 25-mm circular stapler. The type of anastomosis was selected upon surgeon’s preference. Anastomosis was mainly performed as hand-sewn from 2001 to 2012 and changed to a stapler anastomosis routinely using the 25-mm circular intraluminal stapler (Covidien, EEA, DST Series). Operations were only performed by chief or experienced senior surgeons.

Both groups were compared regarding anastomotic leaks and strictures, postoperative morbidity, 90-day mortality and survival.

To assess the severity of perioperative morbidity, the Clavien-Dindo classification was used[22]; the overall postoperative morbidity during first hospital stay (surgical and respiratory complications included) was divided into minor morbidity, corresponding to Clavien-Dindo Grades I-II, and major/lethal postoperative morbidity corresponding to Clavien-Dindo Grades III-V. The group of minor postoperative morbidity consisted of complications treated conservatively. The group of major postoperative morbidity consisted of complications requiring surgical, endoscopic or radiological intervention (Clavien-Dindo Grade III); life-threatening complications requiring ICU management (Grade IV); and lethal complications (Grade V). The mortality during the first hospital stay was divided into 30-, 60- and 90-day mortality.

The disruption of the anastomosis leading to extravasation of intraluminal content was defined as anastomotic leak. The definite diagnosis of anastomotic leak was confirmed endoscopically. Data collection and analysis were performed only on patients who underwent an intrathoracic anastomosis.

Anastomotic stricture was defined as dysphagia in the 6-month endoscopic control requiring intervention (endoscopic dilatation). Patients with anastomotic stricture suffered from Clavien-Dindo Grade III complication.

Tumor management

Endoscopy was performed preoperatively as well as 6 months postoperatively to exclude tumor recurrence. In the preoperative work-up, a computed tomography was performed to detect further organ metastases. Neoadjuvant therapy was carried out preoperatively according to the international guidelines[23]. Surgical resection followed 4-6 weeks after the end of the neoadjuvant therapy. Until 2012, we used the PLF scheme, based on cisplatin, folic acid, 5-fluoruracil and simultaneous irradiation [45 Gy (1.5 Gy per day)] in cases of squamous-cell esophageal carcinoma. Since 2012, we have performed neoadjuvant chemoradiation, as proposed by the Dutch CROSS trial, consisting of weekly administration of carboplatin und paclitaxel for 5 weeks and concurrent radiotherapy (41.4 Gy in 23 fractions) followed by surgery 4-6 weeks later. Cardiopulmonary examinations (electrocardiogram, echocardiogram and lung function test) were performed preoperatively.

Perioperative treatment

Patients received single-shot antibiotics intraoperatively. This included metronidazole 500 mg i.v. and ceftriaxone 2 g i.v. In the case of penicillin allergy, clindamycin 600 mg i.v. was injected. After confirmation of a patent anastomosis-using radiographic control-on Postoperative Day 5, the nasogastric tube was routinely removed. Then, enteral feeding including liquids was started.

Statistical analysis

Statistical analysis was performed using χ² test (chi square test), binary logistic regression and Mann-Whitney U test. Survival data were recorded contacting either the Cancer Registry of Saarland or the house physicians. A 6-month follow-up was routinely performed including endoscopy. Log rank test and Cox regression were performed for survival analysis. Statistical analysis was conducted using IBM SPSS Statistics V22.0 (SPSS, Inc., Chicago, IL, USA).


Patient characteristics, operative data and postoperative outcome

Overall, 126 (71.6%) patients (Group 1) received a hand-sewn anastomosis, while 50 (28.4%) patients (Group 2) received a stapler anastomosis. Patient characteristics were similar in both groups [Table 1]. Median age of patients at the time of surgery was 61 years (34-88 years), with a male-to-female ratio of 153:23. Fifty-two (29.5%) patients were diagnosed with squamous-cell esophageal cancer, and 124 (70.5%) patients with esophageal adenocarcinoma. Forty-five (25.6%) patients had chronic obstructive pulmonary disease (COPD) at the time of surgery, 33 (18.9%) patients coronary heart disease (CHD) and 34 (19.3%) patients were obese. The preoperative rates of COPD (P = 0.13), CHD (P = 0.20) and obesity (P = 0.42) were not significantly different between the groups. In total, 93 (52.8%) patients were admitted to neoadjuvant therapy due to preoperative staging (Group 1: 47.6% vs. Group 2: 66%, P = 0.11).

Table 1

Esophagectomies with intrathoracic anastomosis for esophageal cancer (n = 176): patient characteristics

P value
Age in years, median [min, max]62 [42, 88]61 [34, 84]61 [34, 84]0.34
Men/women ratio n (%)111/15 (88%/12%)42/8 (84%/16%)153/23 (86.9%/13.1%)0.23
Adenocarcinoma of esophagus n (%)86 (68.3%)38 (76%)124 (70.5%)0.21
Squamous-cell carcinoma of esophagus n (%)40 (31.7%)12 (24%)52 (29.5%)0.21
COPD n (%)35 (27.8%)10 (20%)45 (25.6%)0.13
Coronary heart disease n (%)26 (20.6%)7 (14%)33 (18.9%)0.20
Obesity n (%)24 (19%)10 (20%)34 (19.3%)0.42
Neoadjuvant therapy n (%)60 (47.6%)33 (66%)93 (52.8%)0.11

Median duration of surgery was 269 min (128-532 min), whereas the median intraoperative blood loss was 300 mL (5-4000 mL), as shown in Table 2. The median harvest of dissected lymph nodes was 17 (3-62).

Table 2

Esophagectomies with intrathoracic anastomosis for esophageal cancer (n = 176): operative data and postoperative outcome

P value
Duration of surgical procedure median [min, max]280 [128, 532]261 [160, 376]269 [128, 532]0.49
Blood loss in mL median [min, max]300 [50, 4000]200 [5, 1500]300 [5, 4000]0.12
Number of dissected lymph nodes, median [min, max]17 [3, 62]17 [6, 34]17 [3, 62]0.59
Minor postoperative complications
Clavien-Dindo Grade I-II, n (%)
13 (10.3%)10 (20%)23 (13%)0.2
Major postoperative complications
Clavien-Dindo Grade III-IV, n (%)
25 (19.8%)4 (8%)29 (16.5%)0.12
Reoperation, n (%)43 (34.1%)4 (8%)47 (26.7%)0.001***
Respiratory complications, n (%)35 (27.8%)12 (24%)47 (26.3%)0.36
Anastomotic leak, n (%)18 (14.3%)4 (8%)22 (12.5%)0.22
Anastomotic stricture, n (%)17 (13.5%)3 (6%)20 (11.4%)0.1
30-day mortality, n (%)6 (4.8%)0 (0%)6 (4.8%)0.13
60-day mortality, n (%)12 (9.6%)1 (2%)13 (7.4%)0.08
90-day mortality, n (%)17 (13.5%)1 (2%)18 (10.2%)0.02*
Hospital stay in days, median [min, max]21 [9, 198]18 [12, 114]20 [9, 198]0.26

Minor postoperative complications (Clavien-Dindo Grades I-II) were presented in 23 (13%) patients. Major postoperative complications (Clavien-Dindo Grades III-IV) appeared in 29 (16.5%) patients. Thirteen (10.3%) patients in Group 1 and 10 (20%) patients in Group 2 suffered from minor complications, whereas 25 (19.8%) patients in Group 1 and 4 (8%) patients in Group 2 suffered from major complications [Table 2]. More specifically, in Group 1, the distribution of minor complications was as follows: 2 (0.015%) patients with wound infection, 3 (0.02%) with chyle leak, 3 (0.02%) with pneumonia and 5 (0.04%) with pleural effusion. In Group 2, the distribution of minor complications was as follows: 1 (0.02%) patient with wound infection, 1 (0.02%) with chyle leak, 4 (8%) with pneumonia, 6 (0.06%) with pleural effusion and 1 (0.02%) with pneumothorax. The distribution of major complications in Group 1 was as follows: 4 (0.03%) patients with anastomotic leak, 4 (0.03%) with anastomotic leak and simultaneous gastric conduit necrosis, 5 (0.04%) with anastomotic leak and concomitant mediastinitis, 5 (0.04%) with anastomotic leak and respiratory insufficiency, 1 (0.008%) patient with bile leak, 1 (0.008%) with early hiatal hernia, 3 (0.02%) with wound dehiscence and 2 (0.015%) with chyle leak needing reoperation. There were 4 (8%) patients with anastomotic leak in the stapler anastomosis group. Eighteen (10.2%) patients suffered from lethal postoperative complication (Clavien-Dindo Grade V) within 90 days after surgery. There were no significant differences between both groups concerning the incidence of minor and major morbidity, however the 90-day mortality was higher in the hand-sewn anastomosis group (P = 0.02, Table 2).

Minor surgical complications included wound infection and chyle leak treated conservatively, while minor cardiopulmonary complications included pleura effusion treated with diuretics, pneumothorax with no need for draining tube, pneumonia and atrial fibrillation. The minor postoperative morbidity did not differ significantly between the groups (P = 0.2). Major surgical complications included necrosis of gastric conduit enterothorax, hiatal hernia, anastomotic leak, wound dehiscence, bile leak (occurring in one patient in the frame of prophylactic cholecystectomy) and chyle leak with need for reoperation. Surgical complications (anastomotic leak and necrosis of the gastric conduit) led predominantly to major and lethal postoperative morbidity (Clavien-Dindo Grades III-V).

Forty-seven (26.7%) patients were subjected to redo surgery during the first hospital stay. The rate of reoperations differed substantially between both groups (Group 1: 34.1% vs. Group 2: 8%, P = 0.001). The incidence of anastomotic leak was 12.5% (22/176) and did not differ significantly between the groups (Group 1: 14.3% vs. Group 2: 8%, P = 0.22), although it was almost 50% reduced in the stapler anastomosis group. The median hospital stay was 20 days (9-198 days) and did not significantly differ between the groups (P = 0.26). The rate of anastomotic stricture in the 6-month follow-up did not significantly differ between the groups (Group 1: 13.5% vs. Group 2: 6%, P = 0.1), although it was more than 50% reduced in the stapler group. The 30-, 60- and 90-day mortality was 4.8% (n = 6), 7.4% (n = 13) and 10.2% (n = 18), respectively. The 90-day mortality was significantly lower in Group 2 (Group 1: 13.5% vs. Group 2: 2%, P = 0.02). The most apparent differences of surgical outcome when comparing the anastomotic methods were the rate of reoperation and consequently the 90-day mortality [Table 2].

Management of anastomotic leak

In the stapler anastomosis group, anastomotic leaks were treated with endoscopic stent insertion: 4 out of 50 (8%) patients after stapler anastomosis suffered from anastomotic leak, of whom only one was subjected to new surgical procedure and 3 were successfully treated with endoscopic stent insertion. In contrast, in the hand-sewn anastomosis group, anastomotic leaks were predominantly treated with reoperation: 18 patients after hand-sewn anastomosis suffered from anastomotic leak, of whom 14 underwent new surgical procedure and 4 were treated with endoscopic stent insertion. Consequently, 90-day mortality (Clavien-Dindo Grade V complications) and overall survival were statistically significantly different between the groups of patients.

Risk factors for major and lethal postoperative complications (Clavien-Dindo Grades III-V) after abdominothoracic esophageal resection

The type of anastomosis (P = 0.004) and duration of surgery (P = 0.002) significantly influenced the incidence of major and lethal postoperative complications (Clavien-Dindo Grades III-V) in the multivariate analysis (binary logistic regression, Table 3).

Table 3

Univariate and multivariate analysis of predictors of major postoperative complications (Clavien-Dindo III-IV) after resection for esophageal cancer

ParameterUnivariate analysisMultivariate analysis
OR (95%CI)P valueOR (95%CI)P value
Age1.022 (0.998-1.057)0.200
Sex1.745 (0.703-4.331)0.230
CHD1.847 (0.838-4.071)0.130
COPD1.633 (0.802-3.327)0.180
Obesity1.057 (0.465-2.403)0.900
Neoadjuvant therapy0.984 (0.486-1.993)0.964
Duration of surgery0.992 (0.987-0.997)0.003**0.991 (0.986-0.997)0.002**
Type of anastomosis (hand-sewn vs. stapler)3.296 (1.369-7.937)0.008**3.666 (1.499-8.963)0.004**
Intraoperative blood loss1.000 (0.999-1.001)0.68


Overall median patient survival was 18 months (0-121 months). In Group 1, the median survival was 16 months [minimum: 0; maximum: 119; mean: 31; Standard Deviation (SD): 32], whereas, in Group 2, the median survival was 22 months (minimum: 1; maximum: 121; mean: 20; SD: 18). Patients subjected to hand-sewn anastomosis experienced worse overall survival, as did patients with advanced UICC tumor stage (P = 0.001 and P = 0.002, respectively, log rank test), as shown in Table 4 and Figure 1. No significant differences were observed between UICC tumor staging and anastomotic technique (P = 0.355) or between histological type and anastomotic technique (P = 0.175).

Stapler <i>vs.</i> hand-sewn intrathoracic esophagogastric anastomosis: which anastomotic method renders better results?

Figure 1. Cumulative survival after abdomino-thoracic resection with intrathoracic anastomosis for esophageal cancer depending upon the type of anastomosis (P < 0.001, log rank test).

Table 4

Risk factors for worse overall survival after abdomino-thoracic resection with intrathoracic anastomosis for esophageal cancer-univariate analysis

ParameterLog rank for categorical parametersCox regression for continuous parameters
P valueχ2OR (95%CI)P value
Age1.07 (0.997-1.036)0.098
CHD0.950 0.004
COPD0.153 2.039
Obesity0.118 2.446
Neoadjuvant therapy0.060 3.595
Duration of surgery1.002 (0.999-1.004)0.197
Type of anastomosis (hand-sewn vs. stapler)0.001***22.866
Anastomotic leak0.790 0.070
Reoperation0.150 2.108
Intraoperative blood loss1.000 (0.999-1.000)0.658
Minor postoperative complication (Clavien-Dindo I-II)0.810 1.060
Major postoperative complication (Clavien-Dindo III-V)0.100 0.001
Histology (SCC vs. adenocarcinoma)0.310 1.034
UICC tumor stage0.002**16.971

In the multivariate analysis, the type of anastomosis and advanced UICC tumor stage were independent factors that significantly influenced overall survival [Table 5 and Figure 2].

Stapler <i>vs.</i> hand-sewn intrathoracic esophagogastric anastomosis: which anastomotic method renders better results?

Figure 2. Cumulative survival after abdomino-thoracic esophageal resection with intrathoracic anastomosis for cancer depending upon UICC tumor stage (P = 0.001, log rank test).

Table 5

Risk factors for survival after abdomino-thoracic resection for esophageal cancer-multivariate analysis

ParameterCox regression
OR (95%CI)P value
Type of anastomosis0.165 (0.067-0.409)< 0.001***
UICC tumor stage1.371 (1.130-1.663)0.001***


In the present study, we focused on the impact of anastomotic method (intrathoracic stapler vs. hand-sewn esophagogastric anastomosis) on surgical outcome after abdominothoracic esophagectomy for cancer. Our data suggest that the management of anastomotic leak (endoscopic stent insertion vs. reoperation), combined with the use of stapler to perform intrathoracic esophagogastric anastomosis, positively influences postoperative morbidity, mortality and overall survival.

Regarding anastomotic leak rates after abdominothoracic esophageal resection, our incidence of 12.5% is similar to other reported rates. Major/lethal postoperative complications (Clavien-Dindo Grades III-V) were significantly lower in the stapler anastomosis group, obviously due to the lower reoperation rate. It is important to note that, in the hand-sewn anastomosis group, anastomotic leaks were treated with new surgical procedure (14 out of 18 patients with anastomotic leak), contrary to the stapler anastomosis group, thus leading to higher mortality (34.1% reoperation and 13.5% Clavien-Dindo Grade V complications in the hand-sewn anastomosis group, compared to 8% and 2% in the stapler group, respectively). In the same line of evidence, no patient died from anastomotic leak in the stapler anastomosis group due to successful treatment with endoscopic stent insertion. This fact implies that the aggressive management of anastomotic leaks with redo surgery in the hand-sewn anastomosis group significantly worsened the postoperative outcome. In addition, we cannot exclude that the change of the intrathoracic anastomosis method (end-to-end vs. end-to-side) may have influenced the postoperative outcome, as the end of the gastric conduit is the most ischemic part. However, the intrathoracic esophagogastric anastomosis was performed in the height of azygos vein; the tension of the anastomosis is not so high; and the risk of gastric conduit ischemia is lower compared to, for example, in a cervical esophagogastric anastomosis. Therefore, it remains unclear whether the manner of anastomosis substantially influenced the incidence of anastomotic leaks. Moreover, the esophagogastric anastomosis was sewn from 2001 to 2012, and stapled anastomosis predominated thereafter; the era effect cannot be estimated in the significant improvement in outcomes. Both intraoperative blood loss and duration of surgery were comparable between the groups, but lower in the stapler group, in accordance with the results of other observational studies claiming that stapler anastomosis is faster than hand-sewn anastomosis[24].

There are numerous other studies comparing hand-sewn with stapled esophagogastric anastomosis. The majority consist in retrospective, non-randomized studies. Primary end points in these studies were anastomotic leak and stricture rate. The reported results are not unanimous. Several reports showed no difference in anastomotic leak comparing both anastomotic methods, while other reports demonstrated decreased anastomotic leaks with stapler anastomosis. Kim et al.[24] concluded in their systematic review of eight randomized, controlled trials that there was no significant difference in the anastomotic leak or early mortality between the anastomotic methods. One study demonstrated a difference in stricture rates, with fewer after hand-sewn anastomosis (9% vs. 40%, P = 0.003)[25]. Two meta-analyses found no significant difference in the rate of anastomotic leak comparing both anastomotic techniques. However, there are strong limitations to mention: variability of performed surgical procedures, stapler size, end-to-end vs. end-to-side esophagogastric anastomosis, cervical vs. intrathoracic anastomosis, one-row vs. double-row anastomosis and application of neoadjuvant therapy prior to surgery. Our results show no significant differences concerning anastomotic leaks and strictures between both types of anastomosis, however both occurred less frequently (with a 50% reduction) after stapler anastomosis. Moreover, we should also note that the 30-day mortality (often used in previous studies) underestimates in-hospital mortality. Our data also indicate that 90-day mortality more accurately represents the in-hospital mortality. The 90-day mortality was significantly reduced after stapler anastomosis (2% vs. 13.5%).

Simultaneous cholecystectomies were performed in the study period routinely, in order to avoid symptomatic gallstone formation later. Since 1947, it has been hypothesized that there is an increased rate for gallstone formation after gastric surgery[26], as a result of resection of the anterior branch of the vagal nerve interrupting gallbladder innervation, thus disturbing gallbladder emptying and increasing cholecystokinin release[27-29]. Gillen et al.[30] showed that the benefit of simultaneous cholecystectomy in the frame of gastric/esophageal resection does not outweigh the risks, thus not supporting the hypothesis of prophylactic cholecystectomy. This suggestion was based on the 6% incidence of acute/later cholecystectomy and the higher calculated additional morbidity of 0.95% compared with 0.45%[30]. One out of the 176 (0.005%) patients of our study group was submitted to redo surgery because of biliary leak after prophylactic cholecystectomy in the frame of esophageal resection, thus not adding substantial morbidity.

The advantages of the present study are the qualitative homogeneity of the included patients and the thorough analysis of numerous parameters. We chose to include in the analysis only patients subjected to open Ivor-Lewis abdominothoracic esophageal resection with intrathoracic anastomosis. The therapeutic protocol used in our department is also standardized and given in detail. A thorough comparison of various parameters including intraoperative blood loss, duration of surgical procedure, number of reoperations, 30-, 60- and 90-day mortality and overall survival was performed.

The limitations of the present study are its retrospective, non-randomized character and the fact that the numbers of hand-sewn and stapler esophagogastric anastomoses are not equal (126 vs. 50). The management of anastomotic leaks changed during the different time periods, from being more aggressive (redo surgery) in the past to more conservative now (stent insertion), partially explaining the better postoperative outcome in the stapler anastomosis group.

In summary, the use of stapler to perform esophagogastric anastomosis and endoscopic stent insertion to manage anastomotic leak improved the postoperative outcome after abdominothoracic esophageal resection with intrathoracic anastomosis. In the current study, we experienced a lower anastomotic leaking rate and a better overall survival in favor of the group of patients who underwent a circular stapler anastomosis. Further improvement of surgical technique (minimally invasive surgical procedures) and better perioperative care protocols should further minimize anastomotic leaks after esophageal resections for cancer.



Kolokotronis T and Galanis M would like to thank everyone who helped finalizing the project. Professor Dr. med. Matthias Glanemann, Head of Department, University Clinic of Saarland, Clinic for General, Visceral, Vascular, Pediatric and Transplantation Surgery, 66421 Homburg, Germany, is cordially thanked for providing supervision for Dr. T. Kolokotronis doctoral thesis and giving his permission to collect data.

Authors’ contributions

The first author: Kolokotronis T

The last author: Galanis M

Availability of data and materials

Not applicable.

Financial support and sponsorship


Conflicts of interest

Both authors declared that there are no conflicts of interest.

Ethical approval and consent to participate

This publication is part of the doctoral thesis of Kolokotronis T with the title: “Postoperative outcome and overall survival after surgery for esophageal cancer; a retrospective, single- center experience of 320 patients encompassing 14 years”.

Consent for publication

Not applicable.


© The Author(s) 2021.


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Cite This Article

OAE Style

Kolokotronis T, Galanis M. Stapler vs. hand-sewn intrathoracic esophagogastric anastomosis: which anastomotic method renders better results?. Mini-invasive Surg 2021;5:19.

AMA Style

Kolokotronis T, Galanis M. Stapler vs. hand-sewn intrathoracic esophagogastric anastomosis: which anastomotic method renders better results?. Mini-invasive Surgery. 2021; 5: 19.

Chicago/Turabian Style

Kolokotronis, Theodoros, Michail Galanis. 2021. "Stapler vs. hand-sewn intrathoracic esophagogastric anastomosis: which anastomotic method renders better results?" Mini-invasive Surgery. 5: 19.

ACS Style

Kolokotronis, T.; Galanis M. Stapler vs. hand-sewn intrathoracic esophagogastric anastomosis: which anastomotic method renders better results?. Mini-invasive. Surg. 2021, 5, 19.

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© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (, which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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