fig2

Figure 2. Mechanisms of nuclear miRNA-mediated gene regulation. (A) Ago-loaded miRNAs bind promoter sequences to recruit epigenetic enzymes, altering histone marks and Pol II occupancy to either activate or repress transcription. (B) Ago mediates miRNA binding to promoter-associated RNAs (paRNAs), altering histone marks and Pol II occupancy to regulate gene expression. (C) miRNAs interact with the TATA-box to facilitate PIC assembly and regulate transcription. Ago: Argonaute; paRNAs: promoter-associated RNAs; PIC: pre-initiation complex; TBP: TATA-box binding protein; TFIIA: transcription factor II A.