fig1

Figure 1. Development and characteristics of senescence reporter mouse models. Created in BioRender. Luccy Carriman (2025) https://BioRender.com/6i1w5nr. LUC: Luciferase; tdTomato, tdTom: tandem dimer Tomato; SA-β-Gal: senescence-associated β-galactosidase; GCV: ganciclovir; mRFP: monomeric red fluorescent protein; HSV-TK: herpes simplex virus type 1 thymidine kinase; DTR: diphtheria toxin receptor; CAG: CAG promoter; CreER: Cre recombinase - estrogen receptor fusion protein; DT: diphtheria toxin; tdT: tandem dimer Tomato (tdTomato); FKBP-Caspase-8: FK506-binding protein - fused Caspase-8; CNTL: control; NDF: neonatal dermal fibroblast; LNs: lymph node(s); DAPI: 4′,6-diamidino-2-phenylindole; PBS: phosphate-buffered saline.