fig2

Figure 2. Potential targets for immunotherapy of atherosclerosis. IL1β: Interleukin1 beta; IL6: interleukin6; LDL: lowdensity lipoprotein; LOX1: lectinlike oxidized lowdensity lipoprotein receptor1; M1: classically activated (proinflammatory) macrophages; M2: alternatively activated (antiinflammatory) macrophages; oxLDL: oxidized lowdensity lipoprotein; SPM: specialized proresolving mediators; TNFα: tumor necrosis factor alpha; vascular SMCs: vascular smooth muscle cells. Green arrows indicate potential therapeutic targets, whereas red arrows indicate pathophysiological mechanisms involved in atherogenesis.