fig1

Figure 1. Genetic alterations in iCCA. Multi-omic analyses of large patient cohorts have revealed the most prevalent alterations in iCCA. FGFR2 fusions and mutations in IDH1/2 are the most prevalent, while alterations in KRAS, ARID1A, CDKN2A/B, and BAP1 occur at slightly lower frequencies. Other alterations occur in iCCA at low frequencies but are still considered actionable therapeutic targets are herein depicted. Created with https://www.biorender.com/ .