fig3

Figure 3. Frequent genetic alterations in Ras GEFs, Rap and CRK genes in HCC and CCA. The percentage of patients (for Ras GEFs only when ≥ 4%) with genetic alterations for genes from Ras GEFs, Rap and CRK family are shown. The type of these alterations is indicated by the color, as specified in the legend. Mutation data from whole exome sequencing were taken from cBioportal (https://www.cbioportal.org/) from Liver Hepatocellular Carcinoma [TCGA (TCGA-LIHC), Firehose Legacy, 442 samples] and Cholangiocarcinoma [TCGA (TCGA-CHOL), Firehose Legacy, 51 samples]. HCC: Hepatocellular carcinoma; CCA: cholangiocarcinoma.