fig1

Figure 1. Deregulation of the epigenetic PRC2 complex by HBV infection. A: Diagram depicts the PRC2 complex, comprised of the core subunits EZH2, EED and SUZ12, in interaction with RNA helicase DDX5 and lncRNA HOTAIR; B: working model of how HBV infection disrupts the transcriptionally silencing PRC2. HBV infection promotes activation of PLK1^[61,62], which phosphorylates SUZ12. E3 ligase Mex3b ubiquitinates SUZ12, leading to SUZ12 proteasomal degradation^[64]. The functional significance of the phosphorylation of DDX5 by PLK1 remains to be determined (Rahman and Andrisani, unpublished results)