1. Zonga A, Caob H, Wang F. Anticancer polysaccharides from natural resources: a review of recent research. Carbohydr Polym 2012;90:1395-410.

2. Thoppil RJ, Bishayee A. Terpenoids as potential chemopreventive and thera-peutic agents in liver cancer. World J Hepatol 2011;3:228-49.

3. Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer 2013;13:123-35.

4. Qin W, Liu NN, Wang L, Zhou M, Ren H, Bugnard E, Liu JL, Zhang LH, Vendôme J, Hu JS, Xi XG. Characterization of biochemical properties of Bacillus subtilis RecQ helicase. J Bacteriol 2014;196:4216-28.

5. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008;7:11-20.

6. Bauer JH, Goupil S, Garber GB, Helfand SL. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci U S A 2004;101:12980-5.

7. Jamshidzadeh A, Khoshnood MJ, Dehghani Z, Niknahad H. Hepatoprotective activity of Cichorium intybus L. leaves extract against carbon tetrachloride induced toxicity. Iranian J Pharm Res 2006;5:41-6.

8. Kim M, Shin HK. The water-soluble extract of chicory reduces glucose uptake from the perfused jejunum in rats. J Nutr 1996;126:2236-42.

9. Roberfroid MB, Cumps J, Devogelaer JP. Dietary chicory inulin increases whole-body bone mineral density in growing male rats. J Nutr 2002;132:3599-602.

10. Reddy BS, Hamid R, Rao CV. Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 1997;18:1371-4.

11. Wada T, Sugatani J, Terada E, Ohguchi M, Miwa M. Physicochemical characterization and biological effects of inulin enzymatically synthesized from sucrose. J Agric Food Chem 2005;53:1246-53.

12. Roberfroid MB. Inulin-type fructans: functional food ingredients. J Nutr 2007;137:S2493-502.

13. Buriti FC, Cardarelli HR, Filisetti TM, Saad SM. Synbiotic potential of fresh cream cheese supplemented with inulin and Lactobacillus paracasei in co-culture with Streptococcus thermophilus. Food Chem 2007;104:1605-10.

14. Kaur N, Gupta AK. Applications of inulin and oligofructose in health and nutrition. J Biosci 2002;27:703-14.

15. Toyama T, Nakamura H, Harano Y, Yamauchi N, Morita A, Kirishima T, Minami M, Itoh Y, Okanoue T. PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats. Biochem Biophys Res Commun 2004;324:697-704.

16. Yilmaz HR, Iraz M, Sogut S, Ozyurt H, Yildirim Z, Akyol O, Gergerlioglu S. The effects of erdostiene on the activity of some metabolic enzymes during Cisplatin-induced nephrotoxicity in rats. Pharmacol Res 2004;50:287-90.

17. Rault-Nania MH, Demougeot C, Gueux E, Berthelot A, Dzimira S, Rayssiguier Y, Rock E, Mazur A. Inulin supplementation prevents high fructose diet-induced hypertension in rats. Clin Nutr 2008;27:276-82.

18. Frings CS, Fendley TW, Dunn RT, Queen CA. Improved determination of total serum lipids by the sulfo-phospho-vanillin reaction. Clin Chem 1972;18:673-4.

19. Kayamoria Y, Hatsuyama H, Tsujioka T, Nasu M, Katayama Y. Endpoint colorimetric method for assaying total cholesterol in serum with cholesterol dehydrogenase. Clin Chem 1999;45:2158-63.

20. Wahlefeld AW. Determination of serum triglycerides level. In: Bergmeyer H, editor. Methods of enzymatic analysis. New York: Academic Press; 1974. pp. 1831-5.

21. Naito HK, Kwak YS. The evaluation of a new high density lipoprotein cholesterol (HDL-C) technology: selective separation of lipoproteins by magnetic precipitation. Clin Chem 1995;41:S135.

22. Ahmadi SA, Boroumand MA, Gohari-Moghaddam K, Tajik P, Dibaj SM. The impact of low serum triglyceride on LDL-cholesterol estimation. Arch Iran Med 2008;11:318-21.

23. Satheesh MA, Pari L. Effect of pterostilbene on lipids and lipid profiles in streptozotocin-nicotinamide induced type 2 diabetes mellitus. J Appl Biomed 2008;6:31-7.

24. Acosta AA. Direct immunoenzymatic determination of AFP in serum or plasma. J Clin Immunoassays 1983;6:41.

25. Gornall AG, Bardawill CJ, David MM. Determination of serum protein by means of the biuret reaction. J Biol Chem 1949;177:751-66.

26. Doumas BT, Watson WA, Biggs HG. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 1971;31:87-96.

27. Walter MI, Gerade HW. An ultramicromethod for the determination of conjugated and total bilirubin in serum or plasma. Microchem J 1970;15:231-43.

28. Young DS. Effects of drugs on clinical laboratory tests. 4th ed. Washington DC: AACC Press; 2001.

29. Belfield A, Goldberg DM. Normal ranges and diagnostic value of serum 5'nucleotidase and alkaline phosphatase activities in infancy. Arch Dis Child 1971;46:842-6.

30. Tietz NW. Clinical Guide to Laboratory Tests. 3rd ed. Philadelphia, PA: WB Saunders Company; 1995.

31. Goldman R, Kaplan NO, Hall TC. Lactic dehydrogenase in human neoplastic tissues. Cancer Res 1964;24:389-99.

32. Drury RA, Wallington EA, Cancerson R. Carlton's histopathological techniques. 4th ed. Oxford, UK: Oxford University Press; 1976.

33. Sheehan D, Hrapchak B. Theory and practice of histotechnology. 2nd ed. Ohio: Battelle Press; 1980. pp. 189-90.

34. Waller RA, Duncan DB. A Bayes rule for the symmetric multiple comparison problems. J Am Stat Assoc 1969;64:1484-503.

35. Chen B, Ning M, Yang G. Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats. Molecules 2012;17:4672-83.

36. Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. Br Med Bull 1993;49:523-44.

37. Kalaiselvan A, Gokulakrishnan K, Anand T, Akhilesh U, Velavan S. Preventive effect of shorea robusta bark extract against diethylnitrosamine -induced hepatocellular carcinoma in rats. Int Res J Medical Sci 2013;1:2-9.

38. Ahmed MK, Saleh ME, Sayed ME, Shalaby AFK. Anti-inflammatory effect of different propolis extracts in thioacetamide-induced hepatotoxicity in male rat. J Basic Appl Sci 2012;6:29-40.

39. Alshawsh MA, Abdulla MA, Ismail S, Amin ZA. Hepatoprotective effects of orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats. Evid Based Complement Alternat Med 2011;2011:103039.

40. Tapiero H, Ba GN, Couvreur P, Tew KD. Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomed Pharmacother 2002;56:215-22.

41. Jiang HE, Li X, Zhao YX, Ferguson DK, Hueber F, Bera S, Wang YF, Zhao LC, Liu CJ, Li CS. A new insight into Cannabis sativa (Cannabaceae) utilization from 2500-year-old Yanghai Tombs, Xinjiang, China. J Ethnopharmacol 2006;108:414-22.

42. Thangaraju M, Rameshbabu J, Vasavi H, Ilanchezian S, Vinitha R, Sachanandam P. The salubrious effect of tamoxifen on serum marker enzymes, glycoproteins, lysosomal enzyme level in breast cancer women. Mol Cell Biochem 1998;185:85-94.

43. Sako Y, Hosoi-Tanabe S, Uchida D. Fluorescence in situ hybridization using rRNA-targeted probes for simple and rapid identification of the toxic dinoflagellates Alexandrium tamarense and Alexandrium catanella. J Phycol 2004;40:598-605.

44. Kawasaki N, Hamamoto Y, Nakajima T, Irie K, Ozawa H. Periodontal regeneration of transplanted rat molars after cryopreservation. Arch Oral Biol 2004;49:59-69.

45. Di Stefano G, Busi C, Fiume L. Floxuridine coupling with lactosaminated human albumin to increase drug efficacy on liver micrometastases. Dig Liver Dis 2002;34:439-46.

46. Ahmed MB, Hasona NA, Selemain HA. Protective effects of extract from dates (Phoenix Dactylifera L.) and ascorbic acid on thioacetamide-induced hepatotoxicity in rats. Iran J Pharm Res 2008;7:193-201.

47. Maideen NM, Velayutham R, Manavalan G. Activity of prosopis cineraria against N-nitrosodiethylamine induced liver tumors by regulating the levels of tumor marker lipid peroxidation and Antioxidants. AJPLS 2012;2:1-9.

48. Kadir FA, Kassim NM, Abdulla MA, Yehye WA. Hepatoprotective role of ethanolic extract of vitex negundo in thioacetamide-induced liver fibrosis in male rats. Evid Based Complement Alternat Med 2013;2013:739850.

49. Minnady M, Paulraj- Dominic S, Thomas S, Subramanian S. Therapeutic role of edible Mushroom Pleurotus florida on Thioacetamide induced hepatotoxicity in rats. Int J Curr Res 2010;5:041-6.

50. Al-Attar AM. Hepatoprotective influence of vitamin C on Thioacetamide-induced liver cirrhosis in Wistar male rats. J Pharmacol Toxicol 2011;6:218-33.

51. Kobayashi T, Kawakubo T. Prospective investigation of tumor markers and risk assessment in early cancer screening. Cancer 1994;73:1946-53.

52. Patel NH, Condron BG, Zinn K. Pair-rule expression patterns of even-skipped are found in both short- and long-germ beetles. Nature 1994;367:429-34.

53. Iqbal Z, Lateef M, Ashraf M, Jabbar A. Anthelmintic activity of Artemisia brevifolia in sheep. J Ethnopharmacol 2004;93:265-68.

54. Bailey T, Berg P, Sandy C. The effect of high-performance work practices on employee earnings in the steel, apparel, and medical electronics and imaging industries. Ind Labor Relat Rev 2001;54:525-43.

55. Frezza M, Hindo S, Chen D, Davenport A, Schmitt S, Tomco D, Dou QP. Novel metals and metal complexes as platforms for cancer therapy. Curr Pharm Des 2010;16:1813-25.

56. Park MS, De Leon M, Devarajan P. Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol 2002;13:858-65.

57. Paradis V. Histopathology of hepatocellular carcinoma. Recent Results Cancer Res 2013;190:21-32.

58. Omata M, Peters RL, Tatter D. Sclerosing hepatic carcinoma: relationship to hypercalcemia. Liver 1981;1:33-49.

59. Kojiro M, Sugihara S, Kakizoe S, Nakashima O, Kiyomatsu K. Hepatocellular carcinoma with sarcomatous change: a special reference to the relationship with anticancer therapy. Cancer Chemother Pharmacol 1989;23 Suppl:S4-8.

60. Daubioul CA, Taper HS, De Wispelaere LD, Delzenne NM. Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats. J Nutr 2000;130:1314-9.

61. Kim M, Shin HY. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. Southern J Med 2010;103:140-6.

62. Singh RS, Singh RP. Fructooligosaccharides from inulin as prebiotics. Food Technol Biotechnol 2010;48:435-50.

63. Delzenne NM, Daubioul C, Neyrinck A, Lasa M, Taper HS. Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects. Br J Nutr 2002;87 Suppl 2:S255-9.

64. Williams CM, Jackson KG. Inulin and oligofructose: effects on lipid metabolism from human studies. Br J Nutr 2002;87 Suppl 2:S261-4.

65. Kim M, Shin HK. The water soluble extract of chicory influences serum and liver lipid concentrations and fecal lipid excretion in rats. J Nutr 1998;128:1731-6.

66. Brosnahan G, Fraer M. Chronic kidney disease: whom to screen and how to treat, part 1: definition, epidemiology, and laboratory testing. South Med J 2010;103:140-6.

67. Atta AH, Elkoly TA, Mouneir SM, Kamel G, Alwabel NA, Zahe S. Hepatoprotective effect of methanol extracts of zingiber officinale and cichorium intybus. Indian J Pharm Sci 2010;72:564-70.

68. Hassan HA, Yousef MI. Ameliorating effect of chicory (Cichorium intybus L.)-supplemented diet against nitrosamine precursors-induced liver injury and oxidative stress in male rats. Food Chem Toxicol 2010;48:2163-9.

69. Ahmed B, Al-Howiriny TA, Siddiqui AB. Antihepatotoxic activity of seeds of Cichorium intybus. J Ethnopharmacol 2003;87:237-40.

Hepatoma Research
ISSN 2454-2520 (Online) 2394-5079 (Print)


All published articles are preserved here permanently:


All published articles are preserved here permanently: