fig2

Figure 2. Representative interaction network of key miRNAs and signaling axes in adipose-derived EVs. Representative pathways include miR-192-5p/IL-17RA/Smad signaling, miR-125a-3p/PTEN-mediated angiogenesis, and PI3K/AKT/mTOR-related mitophagy. Created in BioRender. Lu, R. (2026) https://BioRender.com/rx8rgpc. ADSCs: Adipose-derived stem cells; EVs: extracellular vesicles; HUVECs: human umbilical vein endothelial cells; miRNAs: microRNAs; PI3K: phosphoinositide 3-kinase; AKT: protein kinase B; mTOR: mechanistic target of rapamycin; IL-17RA: interleukin-17 receptor A; PTEN: phosphatase and tensin homolog.