REFERENCES
1. Kyaw BM, Järbrink K, Martinengo L, Car J, Harding K, Schmidtchen A. Need for improved definition of “chronic wounds” in clinical studies. Acta Derm Venereol. 2018;98:157-8.
3. Rezaie F, Momeni-Moghaddam M, Naderi-Meshkin H. Regeneration and repair of skin wounds: various strategies for treatment. Int J Low Extrem Wounds. 2019;18:247-61.
4. Martinengo L, Olsson M, Bajpai R, et al. Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies. Ann Epidemiol. 2019;29:8-15.
5. Olsson M, Järbrink K, Divakar U, et al. The humanistic and economic burden of chronic wounds: a systematic review. Wound Repair Regen. 2019;27:114-25.
6. Graves N, Phillips CJ, Harding K. A narrative review of the epidemiology and economics of chronic wounds. Br J Dermatol. 2022;187:141-8.
7. Maxant G, Pastrav M, Gogeneata I, Bajcz C, Bertaux AC. Clinical and medico-economic benefits of remote monitoring of chronic wounds. Int Wound J. 2025;22:e70140.
8. Nussbaum SR, Carter MJ, Fife CE, et al. An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds. Value Health. 2018;21:27-32.
9. Hsieh JC, Maisel-Campbell AL, Joshi CJ, Zielinski E, Galiano RD. Daily quality-of-life impact of scars: an interview-based foundational study of patient-reported themes. Plast Reconstr Surg Glob Open. 2021;9:e3522.
10. Pirakitikulr N, Martin JJ, Wester ST. Laser resurfacing for the management of periorbital scarring. Plast Aesthet Res. 2020;7:67.
12. Wynn M. The benefits and harms of cleansing for acute traumatic wounds: a narrative review. Adv Skin Wound Care. 2021;34:488-92.
13. Warriner RA 3rd, Wilcox JR, Carter MJ, Stewart DG. More frequent visits to wound care clinics result in faster times to close diabetic foot and venous leg ulcers. Adv Skin Wound Care. 2012;25:494-501.
14. De Decker I, De Graeve L, Hoeksema H, et al. Enzymatic debridement: past, present, and future. Acta Chir Belg. 2022;122:279-95.
15. Liu E, Hu X, Zhang W, et al. Efficacy and safety of ultrasound-assisted wound debridement in the treatment of diabetic foot ulcers: a systematic review and meta-analysis of 11 randomized controlled trials. Front Endocrinol. 2024;15:1393251.
16. Kataoka Y, Kunimitsu M, Nakagami G, Koudounas S, Weller CD, Sanada H. Effectiveness of ultrasonic debridement on reduction of bacteria and biofilm in patients with chronic wounds: a scoping review. Int Wound J. 2021;18:176-86.
17. Bowers S, Franco E. Chronic wounds: evaluation and management. Am Fam Physician. 2020;101:159-66.
18. Legemate CM, Kwa KAA, Goei H, et al.; HyCon Study Group. Hydrosurgical and conventional debridement of burns: randomized clinical trial. Br J Surg. 2022;109:332-9.
19. Hajhosseini B, Chiou GJ, Dori G, et al. Er:YAG laser vs. sharp debridement in management of chronic wounds: effects on pain and bacterial load. Wound Repair Regen. 2020;28:118-25.
20. Sherrill JD, Finlay D, Binder RL, et al. Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment. PLoS One. 2021;16:e0260095.
21. Karmisholt KE, Banzhaf CA, Glud M, et al. Laser treatments in early wound healing improve scar appearance: a randomized split-wound trial with nonablative fractional laser exposures vs. untreated controls. Br J Dermatol. 2018;179:1307-14.
22. Parikh UM, Mentz J, Collier I, et al. Strategies to minimize surgical scarring: translation of lessons learned from bedside to bench and back. Adv Wound Care. 2022;11:311-29.
23. Nube VL, Alison JA, Twigg SM. Diabetic foot ulcers: weekly versus second-weekly conservative sharp wound debridement. J Wound Care. 2023;32:383-90.
24. Ditmars FS, Kay KE, Broderick TC, Fagg WS. Use of amniotic membrane in hard-to-heal wounds: a multicentre retrospective study. J Wound Care. 2024;33:S44-50.
25. Mathioudaki E, Vitsos A, Rallis MC. Proteolytic enzymes and wound debridement: a literature review. Wounds. 2024;36:357-65.
26. Afzal H, Dawson E, Fonseca R, et al. Negative pressure wound therapy with and without instillation in necrotizing soft tissue infections. Surg Infect. 2024;25:199-205.
27. Matthews MR, Fernández LG, Hermans MH, Chakravarthy D. The efficient application of instilling negative pressure wound therapy with a hypochlorous acid-preserved wound cleanser: a case series and practical advice. Wounds. 2024;36:148-53.
28. Gold MH, McGuire M, Mustoe TA, et al.; International Advisory Panel on Scar Management. Updated international clinical recommendations on scar management: part 2 - algorithms for scar prevention and treatment. Dermatol Surg. 2014;40:825-31.
29. Yang X, Lohsiriwat V, Chang FCS, et al. Real-world management of abnormal scarring using topical silicone gel: expert consensus and case series from the Asian SCARS Expert Group. Drugs Context. 2023;12.
30. Seago M, Shumaker PR, Spring LK, et al. Laser treatment of traumatic scars and contractures: 2020 International Consensus Recommendations. Lasers Surg Med. 2020;52:96-116.
31. Ma Y, Barnes SP, Chen YY, Moiemen NS, Lord JM, Sardeli AV. Influence of scar age, laser type and laser treatment intervals on adult burn scars: a systematic review and meta-analysis. PLoS One. 2023;18:e0292097.
32. Anderson RR, Donelan MB, Hivnor C, et al. Laser treatment of traumatic scars with an emphasis on ablative fractional laser resurfacing: consensus report. JAMA Dermatol. 2014;150:187-93.
33. Du F, Yu Y, Zhou Z, Wang L, Zheng S. Early treatment using fractional CO2 laser before skin suture during scar revision surgery in Asians. J Cosmet Laser Ther. 2018;20:102-5.
34. Nunez JH, Strong AL, Comish P, et al. A review of laser therapies for the treatment of scarring and vascular anomalies. Adv Wound Care. 2023;12:68-84.
35. Zhang Y; Chinese Association of Plastics and Aesthetics Scar Medicine Branch. National expert consensus on early management of scars (2020 version). Zhonghua Shao Shang Za Zhi. 2021;37:113-25. (in Chinese).
36. Lv K, Xia Z; Chinese Consensus Panel on the Prevention and Treatment of Scars. Chinese expert consensus on clinical prevention and treatment of scar. Burns Trauma. 2018;6:27.
37. Shen S, Cai Y, Song X, Xiang W. The efficacy of fractional carbon dioxide laser in surgical scars treatment: a system review and meta-analysis. Aesthetic Plast Surg. 2023;47:340-50.
38. Friedman O, Gofstein D, Arad E, Gur E, Sprecher E, Artzi O. Laser pretreatment for the attenuation of planned surgical scars: a randomized self-controlled hemi-scar pilot study. J Plast Reconstr Aesthet Surg. 2020;73:893-8.
39. Aoki A, Mizutani K, Taniguchi Y, et al. Current status of Er:YAG laser in periodontal surgery. Jpn Dent Sci Rev. 2024;60:1-14.
40. Haykal D, Cartier H, Goldberg D, Gold M. Advancements in laser technologies for skin rejuvenation: a comprehensive review of efficacy and safety. J Cosmet Dermatol. 2024;23:3078-89.
41. Maghfour J, Ozog DM, Mineroff J, Jagdeo J, Kohli I, Lim HW. Photobiomodulation CME part I: overview and mechanism of action. J Am Acad Dermatol. 2024;91:793-802.
43. Thomsen S. Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions. Photochem Photobiol. 1991;53:825-35.
44. Walsh JT Jr, Flotte TJ, Deutsch TF. Er:YAG laser ablation of tissue: effect of pulse duration and tissue type on thermal damage. Lasers Surg Med. 1989;9:314-26.
45. Karkada G, Maiya GA, Arany P, Kg MR, Adiga S, Kamath SU. Dose-response relationship of photobiomodulation therapy and oxidative stress markers in healing dynamics of diabetic neuropathic ulcers in Wistar rats. J Diabetes Metab Disord. 2023;22:393-400.
46. Anderson RR, Parrish JA. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science. 1983;220:524-7.
47. DiPietro LA. Angiogenesis and wound repair: when enough is enough. J Leukoc Biol. 2016;100:979-84.
48. Yu W, Zhu J, Yu W, Lyu D, Lin X, Zhang Z. A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules. J Am Acad Dermatol. 2018;79:479-86.
49. Ma SY, Gong YQ, Zhang WJ, et al. Split-face comparison of the efficacy of picosecond 532 nm Nd:YAG laser and Q-switched 755 nm Alexandrite laser for treatment of freckles. J Cosmet Laser Ther. 2022;24:22-7.
50. Leyane TS, Jere SW, Houreld NN. Cellular signalling and photobiomodulation in chronic wound repair. Int J Mol Sci. 2021;22.
51. Mester E, Spiry T, Szende B. Effect of laser rays on wound healing. Bull Soc Int Chir. 1973;32:169-73.
52. Mester E, Ludány G, Sellyei M, Szende B, Gyenes G, Tota GJ. Studies on the inhibiting and activating effects of laser beams. Langenbecks Arch Chir. 1968;322:1022-7. (in German).
53. Ryu HS, Lim NK, Padalhin AR, et al. Improved healing and macrophage polarization in oral ulcers treated with photobiomodulation (PBM). Lasers Surg Med. 2022;54:600-10.
54. Zhang G, Yi L, Wang C, et al. Photobiomodulation promotes angiogenesis in wound healing through stimulating the nuclear translocation of VEGFR2 and STAT3. J Photochem Photobiol B. 2022;237:112573.
55. Mathioudaki E, Rallis M, Politopoulos K, Alexandratou E. Photobiomodulation and wound healing: low-level laser therapy at 661 nm in a scratch assay keratinocyte model. Ann Biomed Eng. 2024;52:376-85.
56. Barolet AC, Villarreal AM, Jfri A, Litvinov IV, Barolet D. Low-intensity visible and near-infrared light-induced cell signaling pathways in the skin: a comprehensive review. Photobiomodul Photomed Laser Surg. 2023;41:147-66.
57. Kasowanjete P, Houreld NN, Abrahamse H. The effect of photomodulation on fibroblast growth factor and the Ras/MAPK signalling pathway: a review. J Wound Care. 2022;31:832-45.
58. Karu T. Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP. Photomed Laser Surg. 2010;28:159-60.
59. Chung H, Dai T, Sharma SK, Huang YY, Carroll JD, Hamblin MR. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng. 2012;40:516-33.
60. Dompe C, Moncrieff L, Matys J, et al. Photobiomodulation-underlying mechanism and clinical applications. J Clin Med. 2020;9.
61. Glass GE. Photobiomodulation: a review of the molecular evidence for low level light therapy. J Plast Reconstr Aesthet Surg. 2021;74:1050-60.
62. da Silva TG, Ribeiro RS, Mencalha AL, de Souza Fonseca A. Photobiomodulation at molecular, cellular, and systemic levels. Lasers Med Sci. 2023;38:136.
63. Mineroff J, Maghfour J, Ozog DM, Lim HW, Kohli I, Jagdeo J. Photobiomodulation CME part II: clinical applications in dermatology. J Am Acad Dermatol. 2024;91:805-15.
64. Agostinis P, Berg K, Cengel KA, et al. Photodynamic therapy of cancer: an update. CA Cancer J Clin. 2011;61:250-81.
65. Warrier A, Mazumder N, Prabhu S, Satyamoorthy K, Murali TS. Photodynamic therapy to control microbial biofilms. Photodiagnosis Photodyn Ther. 2021;33:102090.
66. Hou C, Zhang L, Wang L, et al. A meta-analysis and systematic review of photodynamic therapy for diabetic foot ulcers. Photodiagnosis Photodyn Ther. 2024;48:104228.
67. Zhang D, Leong ASW, McMullin G. Blue light therapy in the management of chronic wounds: a narrative review of its physiological basis and clinical evidence. Wounds. 2023;35:91-8.
68. Tripodi N, Sidiroglou F, Apostolopoulos V, Feehan J. Transcriptome analysis of the effects of polarized photobiomodulation on human dermal fibroblasts. J Photochem Photobiol B. 2023;242:112696.
69. Francis NC, Yao W, Grundfest WS, Taylor ZD. Laser-generated shockwaves as a treatment to reduce bacterial load and disrupt biofilm. IEEE Trans Biomed Eng. 2017;64:882-9.
70. Yao W, Kuan EC, Francis NC, St John MA, Grundfest WS, Taylor ZD. Laser-generated shockwaves enhance antibacterial activity against biofilms in vitro. Lasers Surg Med. 2017;49:539-47.
71. Orringer JS, Sachs DL, Shao Y, et al. Direct quantitative comparison of molecular responses in photodamaged human skin to fractionated and fully ablative carbon dioxide laser resurfacing. Dermatol Surg. 2012;38:1668-77.
72. Maddaluno L, Urwyler C, Werner S. Fibroblast growth factors: key players in regeneration and tissue repair. Development. 2017;144:4047-60.
73. Werner S, Peters KG, Longaker MT, Fuller-Pace F, Banda MJ, Williams LT. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci U S A. 1992;89:6896-900.
74. Prignano F, Campolmi P, Bonan P, et al. Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair. Dermatol Ther. 2009;22 Suppl 1:S8-15.
75. Bai J, Li L, Kou N, et al. Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis. Stem Cell Res Ther. 2021;12:432.
76. Mirsky N, Krispel Y, Shoshany Y, Maltz L, Oron U. Promotion of angiogenesis by low energy laser irradiation. Antioxid Redox Signal. 2002;4:785-90.
77. Jiang B, Tang R, Zheng D, et al. Evaluation of the efficacy of ultrapulsed CO2 laser in chronic wounds. Lasers Surg Med. 2021;53:443-9.
78. El Nawam H, El Backly R, Zaky A, Abdallah A. Low-level laser therapy affects dentinogenesis and angiogenesis of in vitro 3D cultures of dentin-pulp complex. Lasers Med Sci. 2019;34:1689-98.
79. Keshri GK, Yadav A, Verma S, Kumar B, Gupta A. Effects of pulsed 810 nm Al-Ga-As diode laser on wound healing under immunosuppression: a molecular insight. Lasers Surg Med. 2020;52:424-36.
80. Kang D. Enhancing Skin flap survival with preoperative carbon dioxide fractional laser treatment: a novel approach in reconstructive surgery. J Craniofac Surg. 2025;36:334-8.
81. Cambier S, Gouwy M, Proost P. The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention. Cell Mol Immunol. 2023;20:217-51.
82. Restivo TE, Mace KA, Harken AH, Young DM. Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model. J Trauma. 2010;69:392-8.
83. Schmitt L, Huth S, Amann PM, et al. Direct biological effects of fractional ultrapulsed CO2 laser irradiation on keratinocytes and fibroblasts in human organotypic full-thickness 3D skin models. Lasers Med Sci. 2018;33:765-72.
84. Helbig D, Bodendorf MO, Grunewald S, Kendler M, Simon JC, Paasch U. Immunohistochemical investigation of wound healing in response to fractional photothermolysis. J Biomed Opt. 2009;14:064044.
85. Peña OA, Martin P. Cellular and molecular mechanisms of skin wound healing. Nat Rev Mol Cell Biol. 2024;25:599-616.
86. Rousselle P, Braye F, Dayan G. Re-epithelialization of adult skin wounds: cellular mechanisms and therapeutic strategies. Adv Drug Deliv Rev. 2019;146:344-65.
87. Dillmann WH. Heat shock proteins and protection against ischemic injury. Infect Dis Obstet Gynecol. 1999;7:55-7.
88. Williams RS. Heat shock protein 47: a chaperone for the fibrous cap? Circulation 2000;101:1227-8.
89. Köhler A, Mörgelin M, Gebauer JM, et al. New specific HSP47 functions in collagen subfamily chaperoning. FASEB J. 2020;34:12040-52.
90. Genest O, Wickner S, Doyle SM. Hsp90 and Hsp70 chaperones: collaborators in protein remodeling. J Biol Chem. 2019;294:2109-20.
91. Makboul M, Makboul R, Abdelhafez AH, Hassan SS, Youssif SM. Evaluation of the effect of fractional CO2 laser on histopathological picture and TGF-β1 expression in hypertrophic scar. J Cosmet Dermatol. 2014;13:169-79.
92. Paasch U, Sonja G, Haedersdal M. Synergistic skin heat shock protein expression in response to combined laser treatment with a diode laser and ablative fractional lasers. Int J Hyperthermia. 2014;30:245-9.
93. Salo T, Mäkelä M, Kylmäniemi M, Autio-Harmainen H, Larjava H. Expression of matrix metalloproteinase-2 and -9 during early human wound healing. Lab Investig J Tech Methods Pathol 1994;70:176-82.
94. Kümper M, Zamek J, Steinkamp J, Pach E, Mauch C, Zigrino P. Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair. Eur J Cell Biol. 2022;101:151276.
95. Kostov K, Blazhev A. Changes in serum levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 in Patients with essential hypertension. Bioengineering. 2022;9:119.
96. Shumaker PR, Kwan JM, Badiavas EV, Waibel J, Davis S, Uebelhoer NS. Rapid healing of scar-associated chronic wounds after ablative fractional resurfacing. Arch Dermatol. 2012;148:1289-93.
97. Madni TD, Lu KB, Imran JB, et al. Chronic burn wound treatment by Erbium: YAG fractional ablation: first described report and literature review. Burns. 2019;45:256-8.
98. Lee HN, Bae JM, Goo BCL, Park YM. Promotion of wound healing through low-fluence ablative fractional laser treatment in diabetic mice. Lasers Med Sci. 2019;34:421-5.
99. Guan H, Zhang D, Ma X, et al. Efficacy and safety of CO2 laser in the treatment of chronic wounds: a retrospective matched cohort trial. Lasers Surg Med. 2022;54:490-501.
100. Rohrer TE, Ugent SJ. Evaluating the efficacy of using a short-pulsed erbium:YAG laser for intraoperative resurfacing of surgical wounds. Lasers Surg Med. 2002;30:101-5.
101. Phillips TJ, Morton LM, Uebelhoer NS, Dover JS. Ablative fractional carbon dioxide laser in the treatment of chronic, posttraumatic, lower-extremity ulcers in elderly patients. JAMA Dermatol. 2015;151:868-71.
102. Zhang Y, Liu Y, Cai B, et al. Improvement of surgical scars by early intervention with carbon dioxide fractional laser. Lasers Surg Med. 2020;52:137-48.
103. Weinstein Velez M, Prezzano J, Bell M, Widgerow A. A single center, prospective, randomized, blinded study to evaluate the efficacy and safety of a topical tripeptide/hexapeptide anhydrous gel when used pre- and post- hybrid fractional laser for the treatment of acne scars. Clin Cosmet Investig Dermatol. 2022;15:2763-74.
104. Kuppa SS, Kang JY, Kim JY, et al. Red-light LED therapy promotes wound regeneration by upregulating COL1A1, COL2A1, VEGF and reducing IL-1β for anti-inflammation. Lasers Med Sci. 2025;40:171.
105. Riedemann HI, Marquardt Y, Jansen M, Baron JM, Huth S. Biological effect of laser-assisted scar healing (LASH) on standardized human three-dimensional wound healing skin models using fractional non-ablative 1540 nm Er:Glass or 1550 nm diode lasers. Lasers Surg Med. 2024;56:100-6.
106. Pulumati A, Jaalouk D, Algarin YA, Nouri K. The role of 755-nm alexandrite picosecond laser in melasma management. Arch Dermatol Res. 2023;316:60.
107. Bao MZ, Zhou LB, Zhao L, et al. Efficacy of lidocaine wet compress combined with red-light irradiation for chronic wounds. World J Clin Cases. 2023;11:7277-83.
108. Prudente D, Hauser F, Mettraux G, Di Bella E, Krejci I. Efficacy of one-time application of low-level laser therapy in the management of complications after third molar surgery: a retrospective practice-based study. Am J Dent. 2023;36:21-4.
