fig1
From: What is the role of Brain derived neurotrophic factor in Multiple Sclerosis neuroinflammation?
Figure 1. Intracellular signaling cascades induced by interaction of mature (m-)BDNF with TrkB receptor. Binding of BDNF to TrkB receptor induces its phosphorylation and translocation to cellular membrane. The BDNF/TrkB receptor complex triggers signaling pathways mediated by activation of PI3K, MAPK, PLC-γ, and GTP-ases. All these pathways induced by BDNF cause the enhancement/activation of dendritic growth and branching and growth of neuronal fibers. TrkB: tyrosine kinase B; BDNF: brain derived neurotrophic factor; PI3K: phosphoinositide 3-kinase; Akt: Protein kinase B; PLC: phospholipase C; MAPK: mitogen-activated protein kinase; TrkB: tropomyosin receptor kinase B
