fig2

Figure 2. The yellow players. Heme: Haemoglobin; HO: Heme oxygenase; Fe: Iron; Co: Carbon monoxide; BLV: Biliverdin; BLVR: Biliverdin-reductase; UCB: Unconjugated bilirubin (indirect bilirubin); CYP: Cytochrome oxygenase. The picture shows the “yellow players” (see text) and the tissues able to produce de novo bilirubin, based on the cited literature (Takeda et al.^[7])