1. Davis KD, Taylor SJ, Crawley AP, Wood ML, Mikulis DJ. Functional MRI of pain- and attention-related activations in the human cingulate cortex. J Neurophysiol 1997;77:3370-80.

2. Singer W. Development and plasticity of cortical processing architectures. Science 1995;270:758-64.

3. Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 2005;6:533-44.

4. Zhuo M. Central plasticity in pathological pain. Novartis Found Symp 2004;261:132-45.

5. Zhuo M. Canadian association of neuroscience review: cellular and synaptic insights into physiological and pathological pain. EJLB-CIHR michael smith chair in neurosciences and mental health lecture. Can J Neurol Sci 2005;32:27-36.

6. Zhuo M. Neuronal mechanism for neuropathic pain. Mol Pain 2007;3:14.

7. Zhuo M. A synaptic model for pain: long-term potentiation in the anterior cingulate cortex. Mol Cells 2007;23:259-71.

8. Zhuo M. Long-term potentiation in the anterior cingulate cortex and chronic pain. Philos Trans R Soc Lond B Biol Sci 2013;369:20130146.

9. Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain 1995;118:279-306.

10. Han CJ, O'Tuathaigh CM, van Trigt L, Quinn JJ, Fanselow MS, Mongeau R, Koch C, Anderson DJ. Trace but not delay fear conditioning requires attention and the anterior cingulate cortex. Proc Natl Acad Sci U S A 2003;100:13087-92.

11. Dick BD, Verrier MJ, Harker KT, Rashiq S. Disruption of cognitive function in fibromyalgia syndrome. Pain 2008;139:610-6.

12. Park DC, Glass JM, Minear M, Crofford LJ. Cognitive function in fibromyalgia patients. Arthritis Rheum 2001;44:2125-33.

13. Ramírez-Maestre C, Esteve R, López AE. Cognitive appraisal and coping in chronic pain patients. Eur J Pain 2008;12:749-56.

14. Koechlin E, Ody C, Kouneiher F. The architecture of cognitive control in the human prefrontal cortex. Science 2003;302:1181-5.

15. Likhtik E, Pelletier JG, Paz R, Paré D. Prefrontal control of the amygdala. J Neurosci 2005;25:7429-37.

16. Xu H, Wu LJ, Wang H, Zhang X, Vadakkan KI, Kim SS, Steenland HW, Zhuo M. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci 2008;28:7445-53.

17. Li XY, Ko HG, Chen T, Descalzi G, Koga K, Wang H, Kim SS, Shang Y, Kwak C, Park SW, Shim J, Lee K, Collingridge GL, Kaang BK, Zhuo M. Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science 2010;330:1400-4.

18. Xia Z, Storm DR. The role of calmodulin as a signal integrator for synaptic plasticity. Nat Rev Neurosci 2005;6:267-76.

19. Zhuo M. Cortical excitation and chronic pain. Trends Neurosci 2008;31:199-207.

20. Xia Z, Storm DR. Calmodulin-regulated adenylyl cyclases and neuromodulation. Curr Opin Neurobiol 1997;7:391-6.

21. Wei F, Qiu CS, Kim SJ, Muglia L, Maas JW, Pineda VV, Xu HM, Chen ZF, Storm DR, Muglia LJ, Zhuo M. Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron 2002;36:713-26.

22. Zhao MG, Ko SW, Wu LJ, Toyoda H, Xu H, Quan J, Li J, Jia Y, Ren M, Xu ZC, Zhuo M. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain. J Neurosci 2006;26:8923-30.

23. Chang DJ, Li XC, Lee YS, Kim HK, Kim US, Cho NJ, Lo X, Weiss KR, Kandel ER, Kaang BK. Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons. Proc Natl Acad Sci U S A 2000;97:1829-34.

24. Wu LJ, Steenland HW, Kim SS, Isiegas C, Abel T, Kaang BK, Zhuo M. Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Mol Pain 2008;4:40.

25. Wang H, Xu H, Wu LJ, Kim SS, Chen T, Koga K, Descalzi G, Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Sci Transl Med 2011;3:65ra3.

26. Zhang MM, Liu SB, Chen T, Koga K, Zhang T, Li YQ, Zhuo M. Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain. Mol Brain 2014;7:47.

27. Li Y, Ji A, Weihe E, Schäfer MK. Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFa) and TNF receptors in rat dorsal root ganglion. J Neurosci 2004;24:9623-31.

28. Tchelingerian JL, Quinonero J, Booss J, Jacque C. Localization of TNF alpha and IL-1 alpha immunoreactivities in striatal neurons after surgical injury to the hippocampus. Neuron 1993;10:213-24.

29. Beattie EC, Stellwagen D, Morishita W, Bresnahan JC, Ha BK, Von Zastrow M, Beattie MS, Malenka RC. Control of synaptic strength by glial TNFalpha. Science 2002;295:2282-5.

30. Leung L, Cahill CM. TNF-alpha and neuropathic pain--a review. J Neuroinflammation 2010;7:27.

31. Jin X, Gereau RW, 4th. Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. J Neurosci 2006;26:246-55.

32. Jia D, Gao GD, Liu Y, He SM, Zhang XN, Zhang YF, Zhao MG. TNF-alpha involves in altered prefrontal synaptic transmission in mice with persistent inflammatory pain. Neurosci Lett 2007;415:1-5.

33. Luster AD. Chemokines--chemotactic cytokines that mediate inflammation. N Engl J Med 1998;338:436-45.

34. Murphy PM. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Factor Rev 1996;7:47-64.

35. Baggiolini M. Chemokines and leukocyte traffic. Nature 1998;392:565-8.

36. Ehrlich LC, Hu S, Sheng WS, Sutton RL, Rockswold GL, Peterson PK, Chao CC. Cytokine regulation of human microglial cell IL-8 production. J Immunol 1998;160:1944-8.

37. Cui GB, An JZ, Zhang N, Zhao MG, Liu SB, Yi J. Elevated interleukin-8 enhances prefrontal synaptic transmission in mice with persistent inflammatory pain. Mol Pain 2012;8:11.

38. Südhof TC. The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 1995;375:645-53.

39. Isao T, Akiyama K. Effect of acute and chronic treatment with methamphetamine on mRNA expression of synaptotagmin IV and 25 KDa-synaptic-associated protein in the rat brain. Psychiatry Clin Neurosci 2004;58:410-9.

40. Janz R, Südhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 1999;24:687-700.

41. Zhang Z, Wang D, Sun T, Xu J, Chiang HC, Shin W, Wu LG. The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses. J Neurosci 2013;33:9169-75.

42. Antonova I, Arancio O, Trillat AC, Wang HG, Zablow L, Udo H, Kandel ER, Hawkins RD. Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. Science 2001;294:1547-50.

43. Lynch MA, Voss KL, Rodriguez J, Bliss TV. Increase in synaptic vesicle proteins accompanies long-term potentiation in the dentate gyrus. Neuroscience 1994;60:1-5.

44. Jaken RJ, Joosten EA, Knüwer M, Miller R, van der Meulen I, Marcus MA, Deumens R. Synaptic plasticity in the substantia gelatinosa in a model of chronic neuropathic pain. Neurosci Lett 2010;469:30-3.

45. Hung KL, Wang SJ, Wang YC, Chiang TR, Wang CC. Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain. Pain 2014;155:377-87.

46. Lee HK, Safieddine S, Petralia RS, Wenthold RJ. Identification of a novel SNAP25 interacting protein (SIP30). J Neurochem 2002;81:1338-47.

47. Bennett MK, Calakos N, Scheller RH. Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science 1992;257:255-9.

48. Peng G, Han M, Du Y, Lin A, Yu L, Zhang Y, Jing N. SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain. J Biol Chem 2009;284:30138-47.

49. Han M, Xiao X, Yang Y, Huang RY, Cao H, Zhao ZQ, Zhang YQ. SIP30 is required for neuropathic pain-evoked aversion in rats. J Neurosci 2014;34:346-55.

50. Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 2002;25:1862-8.

51. Edwards JL, Vincent AM, Cheng HT, Feldman EL. Diabetic neuropathy: mechanisms to management. Pharmacol Ther 2008;120:1-34.

52. Boric M, Jelicic Kadic A, Ferhatovic L, Sapunar D, Puljak L. Calcium/calmodulin-dependent protein kinase II in dorsal horn neurons in long-term diabetes. Neuroreport 2013;24:992-6.

53. Kinoshita J, Takahashi Y, Watabe AM, Utsunomiya K, Kato F. Impaired noradrenaline homeostasis in rats with painful diabetic neuropathy as a target of duloxetine analgesia. Mol Pain 2013;9:59.

54. Tan AM, Samad OA, Fischer TZ, Zhao P, Persson AK, Waxman SG. Maladaptive dendritic spine remodeling contributes to diabetic neuropathic pain. J Neurosci 2012;32:6795-807.

55. Joghataie MT, Roghani M, Jalali MR, Baluchnejadmojarad T, Sharayeli M. Dendritic spine changes in medial prefrontal cortex of male diabetic rats using golgi-impregnation method. Arch Iran Med 2007;10:54-8.

56. Li W, Wang P, Li H. Upregulation of glutamatergic transmission in anterior cingulate cortex in the diabetic rats with neuropathic pain. Neurosci Lett 2014;568:29-34.

57. Chan S, Kilby MD. Thyroid hormone and central nervous system development. J Endocrinol 2000;165:1-8.

58. Abduljabbar MA, Afifi AM. Congenital hypothyroidism. J Pediatr Endocrinol Metab 2012;25:13-29.

59. Baldini IM, Vita A, Mauri MC, Amodei V, Carrisi M, Bravin S, Cantalamessa L. Psychopathological and cognitive features in subclinical hypothyroidism. Prog Neuropsychopharmacol Biol Psychiatry 1997;21:925-35.

60. Aloisi AM, Vodo S, Buonocore M. Pain and thyroid hormones. Neurol Sci 2013;34:1501-8.

61. Guasti L, Marino F, Cosentino M, Cimpanelli M, Rasini E, Piantanida E, Vanoli P, De Palma D, Crespi C, Klersy C, Maroni L, Loraschi A, Colombo C, Simoni C, Bartalena L, Lecchini S, Grandi AM, Venco A. Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: a longitudinal study in hypothyroidism and during hormone treatment. Clin J Pain 2007;23:518-23.

62. Alves IG, da Cruz KM, Mota CM, de Santana DS, Gaujac DP, de Carvalho VC, Reis LC, Sluka KA, Quintans-Junior LJ, Antoniolli AR, Desantana JM, Badauê-Passos D Jr, de Santana-Filho VJ. Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats. Eur J Pain 2013;17:1291-8.

63. Yi J, Zheng JY, Zhang W, Wang S, Yang ZF, Dou KF. Decreased pain threshold and enhanced synaptic transmission in the anterior cingulate cortex of experimental hypothyroidism mice. Mol Pain 2014;10:38.

64. Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge GL, Zhuo M. Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron 2015;85:377-89.

65. Zhuo M. Neural mechanisms underlying anxiety-chronic pain interactions. Trends Neurosci 2016;39:136-45.

66. Yamanaka M, Tian Z, Darvish-Ghane S, Zhuo M. Pre-LTP requires extracellular signal-regulated kinase in the ACC. Mol Pain 2016; doi: 10.1177/1744806916647373.

67. Koga K, Yao I, Setou M, Zhuo M. SCRAPPER selectively contributes to spontaneous release and presynaptic long-term potentiation in the anterior cingulate cortex. J Neurosci 2017;37:3887-95.

Neuroimmunology and Neuroinflammation
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