fig2

Figure 2. TIMPs remain largely unaltered by minocycline treatment after SCI. TIMP-1 was the only inhibitor that was altered (upregulated) by injury compared to naïve controls, and there was no effect of minocycline treatment with the exception of an increase of TIMP-4 at 1 day after SCI. Values are mean ± SEM of 4 samples from vehicle (V) or minocycline (M) group, at 1, 2 or 5 days after injury. *P < 0.05, **P < 0.01 and ***P < 0.001 compared to naïve controls (one-way ANOVA with Tukey's multiple comparisons). TIMPs: tissue inhibitors of metalloproteinases; SCI: spinal cord injury