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Figure 1. The anatomy of SVZ and the genetic alterations in HGG patients. A: Anatomical structure of the human brain SEZ and SVZ; B: copy number aberrations of three SVZ samples from different patients share hallmarks of HGG such as amplification of EGFR and loss/deletion of PTEN. SP42 and R4 display also loss of CDKN2A, another hallmark of the disease. SP14 also exhibits amplification of AKT3 whereas SP42 shows amplification of CDK6 and MET as well. This clearly confirms the aberrant nature of SVZ cells. HGG: high grade glioma; SEZ: sub-ependymal zone; SVZ: sub-ventricular zone