fig2

Figure 2. Haematoxylin-eosin stained brain sections of early embryo (×40) (A), late embryo (×40) (B), neonate (×40) (C) and young adult (×100) (D). (A) Different neuroglia precursor cells and a huge number of predicted myeloid cells of forming ventricular margin radiate towards outer cortex and colonize there. Migration was indicated by arrows (yellow), ventricular margins by orange arrowheads and outer cortex by green arrowheads; (B) a distinct band of cells with a definite organisation appears at the margin (indicated by arrows) but immediately after that diffused cell matrix with scattered cells is observed; (C) in case of neonates along with oligodendrocytes, astrocytes, neuronal cells, a prominent blood capillary with extravasation (indicated by red arrow) of amoeboid monocytic cells out of the BBB is visible. A cell also tethered to the margin of the capillary (indicated by yellow arrow); (D) gathering (indicated by red arrows) and infiltration (indicated by yellow arrows) of blood vessel containing leukocytes into the brain parenchyma to form a stable population of monocytic cells. Perivascular macrophage/microglia are also observed