fig1

Figure 1. Exemplary images of immunohistochemical evaluation of isocitrate dehydrogenase (IDH-1 [R132H]) and karyopherin a2 (KPNA2) expression as well as nuclear accumulation of p53 protein. Immunohistochemical staining with antibodies against mutated IDH-1 (R132H) shows a strong cytoplasmic immunoreactivity in the tumor cells. Nuclear expression of KPNA2 is detected in a subpopulation of tumor cells. Nuclear p53 accumulation can be observed in > 50% of the tumor