Topic: Exosomes (Extracellular Vesicles; EVs) in Vascular Biology, Cardiovascular Physiology and Medicine: Intercellular Communication and Therapeutics

Extracellular vesicles (EVs), including microvesicles, have emerged as important mediators of intercellular and inter-organ communication in vascular, cardiopulmonary, and cardiovascular biology. Since our previous Special Issue, “Microvesicles and Exosomes in Vascular Biology,” published in 2020, the field has advanced substantially, with increasing focus on EV heterogeneity, molecular cargo, multi-omics characterization, and their roles in vascular inflammation, remodeling, thrombosis, cardiometabolic diseases, and vascular aging.

This Special Issue, “Exosomes (Extracellular Vesicles; EVs) in Vascular Biology, Cardiovascular Physiology and Medicine: Intercellular Communication and Therapeutics,” aims to highlight these recent advances and future opportunities. In addition to fundamental mechanisms of EV-mediated vascular communication, we welcome studies on EV-based biomarkers and liquid biopsy, immune–vascular crosstalk, engineered EVs and targeted delivery, regenerative and cell-free therapies, as well as EV manufacturing, standardization, safety, and clinical translation. We hope this Special Issue will provide an updated perspective on how EV research is moving from mechanistic discovery toward precision medicine and therapeutic applications in vascular and cardiovascular diseases.

We welcome Original Research Articles, Reviews, Perspectives, Opinions, Commentaries, and other relevant article types.

Topics of interest include, but are not limited to:

● Structure of EVs and Microvesicles;

● Methods of isolation and Analysis of EVs and Microvesicles;

● EVs and Microvesicles Originating from sub-cellular organelles like mitochondria;

● EV Biology, Biogenesis and Heterogeneity;

● EV Cargo, Multi-omics and Molecular Signatures;

● EV–Endothelium–Smooth Muscle Cell Crosstalk;

● EVs in Atherosclerosis and Plaque Biology;

● EVs and Immune–Vascular Crosstalk;

● EVs in Vascular Remodeling, Angiogenesis and Fibrosis;

● EVs in Cardiometabolic and Vascular Aging;

● EVs in Cardiovascular and Pulmonary Vascular Diseases;

● EVs and Microvesicles in Inflammation – Role of Eicosanoids in Vasculature;

● EVs as Biomarkers for Precision Cardiovascular Medicine;

● Engineered EVs and Targeted Therapeutic Delivery;

● EV-Based Regenerative and Cell-Free Cardiovascular Therapy;

● EV Technology: Manufacturing, Standardization, Safety and Regulatory Translation.

Exosomes, extracellular vesicles (EVs), intercellular communication, EV heterogeneity, cardiovascular diseases, biomarkers, EV Therapeutics