Topic: Vascular Remodeling and Homeostasis: Bridging Mechanisms to Vascular Pathologies

Cardiovascular diseases are the leading cause of mortality worldwide, with nearly 90% of cases attributed to vascular pathology. Vascular homeostasis is fundamental for maintaining organ perfusion, whereas its disruption drives maladaptive remodeling, leading to vasomotor dysfunction, multi-organ injury, and serious threats to human health.

This Special Issue focuses on mechanistic insights into vascular homeostasis and pathological remodeling. Topics will include the regulation and disruption of vascular stability in major conditions such as coronary artery disease, stroke, pulmonary hypertension, aortic aneurysm, ocular vascular disorders, and peripheral ischemic diseases. It will also explore the contribution of vascular dysfunction to other critical conditions, including cancer, diabetic vascular complications, chronic kidney disease, and neurodegenerative disorders such as Alzheimer’s disease. Particular emphasis will be placed on the roles of vascular smooth muscle cells, endothelial cells, and immune cells in tension regulation, structural remodeling, and immune imbalance. By uncovering key signaling networks and potential therapeutic targets, this issue aims to provide new insights and innovative strategies for the prevention and treatment of vascular diseases.

Recommended topics:

1. Epidemiology and Risk Factors of Vascular Diseases: Global trends and regional disparities;

2. Gut Microbiota in Vascular Injury and Related Diseases;

3. Impact of Infectious Diseases on Vascular Structure and Function;

4. Mechanisms of Vascular Remodeling in Pulmonary Hypertension;

5. Chronic Kidney Disease and Vascular Dysfunction: Pathophysiological interactionsbetween renal and systemic vasculature;

6. Vascular Homeostasis and the Tumor Microenvironment: Angiogenesis, immune suppression, and metastatic potential;

7. Metabolic Disorders and Vascular Diseases: Mechanistic links amongdiabetes, obesity, and endocrine regulation;

8. Hemodynamic Stress and Vascular Remodeling: Mechanosensation and signal transduction;

9. Vascular Smooth Muscle Cell Phenotypic Switching and Pathological Remodeling;

10. Endothelial Dysfunction and Multi-Organ Vascular Diseases: From molecular mechanisms to clinical relevance;

11. Vascular Immune and Inflammatory Responses: Roles of innate and adaptive immunity in pathological remodeling;

12. Vascular Aging and Remodeling: Telomere regulation, cellular senescence, and signaling networks;

13. Lymphatic Function and Vascular Homeostasis: Fluid balance, immune modulation, and disease associations;

14. Lymphatic Remodeling and Pathological Transformation: Roles in atherosclerosis, tumor metastasis, and inflammatory disorders;

15. Vascular Organoids: Modeling Vascular Development, Homeostasis, and Disease;

16. Engineering Functional Vascular Organoids for Regenerative and Translational Medicine.

Vascular homeostasis, vascular remodeling, endothelial dysfunction, vascular inflammation, hemodynamic stress, vascular aging, lymphatic remodeling, vascular organoids and regenerative medicine