Topic: Scar Tissue Prevention and Revision
A Special Issue of Plastic and Aesthetic Research
ISSN 2349-6150 (Online) 2347-9264 (Print)
Submission deadline: 15 May 2020
Special Issue Introduction
The final remodeling phase of the healing process includes maturation and scar formation. A reduction in extracellular matrix deposition is observed as is a considerable loss of various cell types, including myofibroblasts (the major cell type involved in granulation tissue formation), which occurs by apoptosis. Inappropriate delay of apoptosis, thus increasing survival of myofibroblasts, may be a factor underlying pathological states including excessive scarring.
Interestingly, it has been suggested that an excessively long inflammatory phase, the phase which normally develops immediately after the lesion, can favor the development of pathological scars. How can we avoid the appearance of these pathologies? Is manipulation of the early-stage wound the right strategy for scar prevention? Is the use of mesenchymal stem/stromal cells that show trophic and anti-inflammatory properties a good option?
What are the different approaches currently proposed for treating scarring pathologies? Are surgical intervention and radiotherapy, laser therapy, corticosteroids and 5-fluorouracil treatment, and cryotherapy, useful options?
The applications of skin substitutes, not forgetting application of silicone and mechanical manipulation of the scar, are also alternatives.
All of these aspects of pathological scarring will be discussed in this Special Issue.
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Submission Deadline: 15 May 2020
Contacts: Smart Zhang, Managing Editor, email@example.com