Topic: Basic Science and Clinical Perspectives on Scar Formation and Regenerative Healing

Dear Colleagues,

We invite authors to submit manuscripts for a special issue devoted to the evolving landscape of scar management and reconstruction, titled "Basic Science and Clinical Perspectives on Scar Formation and Regenerative Healing."

Scars are more than just cutaneous marks; they represent the culmination of biological healing and, for many patients, a lifelong physical and psychological burden. In recent years, the field of scar management has undergone a paradigm shift, moving from simple surgical revision to a multifaceted approach that integrates advanced mechanobiology, regenerative medicine, and precision surgical techniques.

This special issue aims to bridge the gap between basic research and clinical application. We seek high-quality original research, comprehensive reviews, and technical notes that highlight the latest innovations in scar prevention, assessment, and treatment.

Guest Editor

Recommended topics for the special issue include:

● Mechanobiology of Scarring: Understanding how physical tension influences scar formation and the latest tension-shielding technologies;

● Keloid and Hypertrophic Scar Management: Multi-modal protocols combining surgery, radiotherapy, laser therapy, and internal medicine;

● Advanced Surgical Revision: Novel Z-plasty variations, local flap designs, and micro-dissection techniques for functional and aesthetic restoration;

● Regenerative Approaches: The role of fat grafting, SVF (Stromal Vascular Fraction), and PRP (Platelet-Rich Plasma) in scar remodeling;

● Innovations: Botulinum toxin, and the use of AI/imaging for scar assessment and prediction;

● Patient-Centered Outcomes: Psychological impact of scarring and objective metrics for quality-of-life improvements;

● Fibroblast heterogeneity and cellular dynamics in wound healing and regeneration.

Scar formation, regenerative healing, mechanobiology, scar management, keloid, hypertrophic scar, scar reconstruction, reconstructive surgery