Topic: Bone and Soft Tissue Repair

Tissue regeneration and repair represent one of the most dynamic and promising frontiers in regenerative medicine and biomedical engineering. Bone and soft tissues (including cartilage, tendon, nerve, blood vessels, and skin) are frequently damaged as a result of trauma, congenital defects, degenerative diseases, or tumor resection. However, the intrinsic regenerative capacity of these tissues is often limited, posing significant challenges to clinical treatment. In this context, biomaterials and bioactive materials have emerged as core tools to modulate the microenvironment of damaged tissues, guide cell proliferation, differentiation and extracellular matrix deposition, and ultimately restore tissue structure and function. The aim of this Special Issue is to highlight cutting-edge research and recent advances in biomaterials for bone and soft tissue repair and regeneration. We encourage materials scientists, chemists, and clinical investigators to contribute papers reflecting the latest progress in their respective research fields.

Topics include, but are not limited to:

● Functional and image-guided (visualizable) biomaterials forbone and soft tissue repair; 

● Bone and soft tissue repair materials incorporating stem cells, exosomes, or nanoparticles;

● Bone and soft tissue repair materials fabricated using three-dimensional (3D)printing, electrospinning, or molding techniques;

● Immunomodulatory bioactive materials forbone and soft tissue repair;

● Design, synthesis,and characterization of novel hydrogels, microspheres, nanospheres, fibrous scaffolds, and 3D-printed composite scaffolds for bone and soft tissue repair and regeneration;

● Mechanistic studies on interactions between biomaterials and cells, extracellular matrix, andthe host immune microenvironment;

● Preclinical and clinical translational research onbiomaterial-based scaffolds for bone and soft tissue repair;

● In vivoevaluation of biomaterial biocompatibility, biodegradability, mechanical properties, and long-term safety.