Topic: Intestinal Bacteria and Colorectal Cancer: Etiology and Treatment

Colorectal cancer ranks as one of the most common cancers worldwide, with the third-highest mortality and the fourth-highest incidence. Emerging evidence links gut microbiota to the initiation, progression, and prognosis of colorectal cancer. Through omics methods and wet lab experiments, a few pathogenic bacteria have been pinpointed within the human gut microbiota, playing pivotal roles in causing inflammatory bowel disease and/or colorectal cancer. Additionally, a range of metabolites secreted by pathogenic bacteria or probiotic bacteria have been tested for their significant influence on, or regulation of, host intestinal homeostasis, including immune system responses and energy metabolism. Despite ongoing debates surrounding the roles of certain species and metabolites, substantial advances have been made in the field. Further characterization of bacterial species from the gut microbiota and metabolites, as well as an understanding of their functioning mechanisms, will provide a molecular basis for the development of novel treatment strategies.

This Special Issue focuses on the mechanisms by which gut microbiota or their metabolites impel the initiation, progression, and prognosis of colorectal cancer. Additionally, we welcome novel strategies tested for colorectal cancer treatments and bioinformatics analyses of the impacts of gut microbiota on treatment and prognosis. All manuscript types are encouraged, including but not limited to research articles, observational studies, meta-analyses, perspectives, s, etc. The main themes include, but are not limited to, the below lists:
● Roles of bacterial species/metabolites involved in stage-specific or location-specific colorectal cancer;
● Carcinogenic interactions between bacterial species/metabolites and host systems in gut;
● Roles of bacterial species/metabolites in clinical treatment and prognosis;
● Novel strategies involving gut microbiota for colorectal cancer treatment.

31 Aug 2024