Special Issue

Topic: Genetics and Epigenetics of Prostate Cancer: from Etiology to Treatment
A Special Issue of Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
Submission deadline: 30 Mar 2021
Guest Editor
Special Issue Introduction
Prostate cancer is the second leading cause of death in men and its development and progression is dependent on androgens/androgen receptor. The etiology of prostate cancer still remains elusive with genetic, epigenetic, environmental, and lifestyle factors associated with increased disease risk. The post-genome era research on prostate cancer has identified genetic variations associated with the disease including potential germline polymorphisms and allelic imbalances linked with prostate cancer susceptibility. Epigenetic mechanisms such as DNA hyper- or hypo- methylation, histone modifications and involvement of non-coding RNAs in gene transcription permit unchanging inheritance of phenotypes without changes in the DNA sequence. Such epigenetic modifications are developed as biomarkers for early detection, stratification and risk assessment of prostate cancer. In addition, current treatment options and novel drug combinations have strong potential for durable therapeutic responses and eventual cures for advanced disease. Improved disease management will also benefit from artificial intelligence-based decision support for disease prognosis and appropriate standard of care to minimize overtreatment of localized disease, and new standards of care augmented by next-generation adaptive clinical trials. The aim of this Special Issue on prostate cancer is to provide an updated knowledge on the epidemiology, etiology, diagnosis and treatment of prostate cancer.
Keywords
Prostate Cancer, genetics, epigenetics
Submission Deadline
30 Mar 2021
Submission Information
For Author Instructions, please refer to https://www.oaepublish.com/jtgg/author_instructions
For Online Submission, please login at https://www.oaecenter.com/login?JournalId=jtgg&IssueId=jtgg210331502
Submission Deadline: 31 Mar 2021
Contacts: Jixiang Zhao, Assistant Editor, [email protected]
Published Articles
The endocrine and epigenetic impact of persistent cow milk consumption on prostate carcinogenesis
Open Access Review 6 Jan 2022
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The effect of HMGB1 and RAGE on the clinicopathological and prognostic features of prostate cancer
Open Access Review 4 Nov 2021
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Genomic characterization of treatment-associated small cell neuroendocrine carcinoma of the prostate
Open Access Review 2 Aug 2021
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The association between genetic variants in HSD3B1 and clinical management of PCa
Open Access Review 16 Jun 2021
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An update of aberrant methylation detection on circulating cell-free DNA as a tool to improve prostate cancer diagnosis and prognosis
Open Access Review 1 Jun 2021
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Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD1
Open Access Original Article 27 May 2021
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Prostate cancer in young men represents a distinct clinical phenotype: gene expression signature to predict early metastases
Open Access Original Article 8 Mar 2021
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Adenoid cystic carcinoma of the prostate: an unusual subtype of prostate cancer
Open Access Case Report 12 Nov 2020
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