Special Issue

Topic: Genomic Landscape of Hereditary Breast Cancer: Unraveling Novel Genetic Markers

A Special Issue of Journal of Translational Genetics and Genomics

ISSN 2578-5281 (Online)

Submission deadline: 31 Dec 2024

Guest Editor(s)

Prof. Giuseppe Novelli
Lab. Medical Genetics, Tor Vergata University of Rome, Rome, Italy.
Prof. Laura Ottini
Department of Molecular Medicine, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Rome, Italy.

Special Issue Introduction

Almost three decades have passed since the discovery of BRCA1 and BRCA2, the main genes associated with hereditary breast cancer. Since then, a multitude of other susceptibility genes have been uncovered, each exerting unique influences on the lifetime risk of developing breast cancer. Notably, high-to-moderate penetrance alleles, particularly within genes involved in DNA double-strand break repair via homologous recombination (HR), have been identified, largely thanks to the widespread adoption of high-throughput technologies, especially next-generation sequencing (NGS), in both research and clinical contexts. 

The mutation status of BRCA1/BRCA2 has also emerged as a predictive biomarker in the treatment of breast cancer patients using PARP inhibitors in routine clinical practice. Additionally, other genetic defects in HR and DNA repair pathways may contribute to inherent or acquired sensitivity to PARP inhibitors. Thus, while expanding our understanding of genetic factors in breast cancer is crucial for more effective risk assessment and management in familial cases, some of these genetic alterations may also serve as predictive biomarkers for targeted molecular therapies.

The utilization of omics technologies has currently facilitated the comprehensive profiling of breast cancer, profoundly influencing our understanding of breast cancer biology and offering data with potential clinical implications.

The objective of this Special Issue is to provide updated insights into the genomic landscape of hereditary breast cancer, aiming to uncover biomarkers predictive of cancer risk and treatment response, representing a fundamental step toward precision oncology for breast cancer patients.

Submission Deadline

31 Dec 2024

Submission Information

For Author Instructions, please refer to https://www.oaepublish.com/jtgg/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=jtgg&SpecialIssueId=jtgg240416
Submission Deadline: 31 Dec 2024
Contacts: Jixiang Zhao, Assistant Editor, jixiang.zhao@jtggjournal.com

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Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
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