Topic: Beyond Liquid Biopsy: Extracellular Vesicles for Biomarker Discovery of Human Diseases

Extracellular vesicles (EVs) are released by every cell type and are present in any clinically relevant sample, with many pathological conditions resulting in increased release of EVs amount and/or in their molecular cargo. EVs reflect the state of their cells of origin, act as functional carriers and may serve as therapeutic agents, thus constituting a state-of-the-art complement to liquid biopsy in biomarker discovery and identification of novel therapeutic targets.

Multi-omics approaches have unparalleled sensitivity, high-throughput sampling capacity, and capability of identifying thousands of molecules in one-single analysis, facilitating biomarker discovery as well as unveiling unprecedented molecular mechanisms through the study of EVs.

For this Special Issue, we welcome EV-based research articles, reviews, new insights and perspectives including, but not limited to, the topics underlined below:
● Cell type derived EVs as biomarkers in biological fluids;
● EV cargoes as biomarkers of human disease;
● Development of EV-based clinical assays;
● Biological role of EVs´ tetraspanins in human disease;
● Omics analyses of EVs (proteomic, transcriptomic and/or metabolomic);
● Methodological advances in biomarker discovery and omics applied to EVs.

31 Mar 2024