Topic: Animal Models of Different Species for Investigating Neurodegenerative Diseases

Animal models are essential to the investigation of neurodegenerative diseases and the development of effective treatment. Genetically modified rodents have been widely used to model neurodegenerative diseases and provided important insights into disease pathogenesis. Recently developed gene-editing tool CRISPR-Cas9 also allowed the generation of large animal (rabbit, pig, monkey) models that can recapitulate important pathological features seen in the patient brains. This Special Issue will discuss the strengths and limitations of animal models of different species and provide an overview for using animal models to better understand the pathogenesis of neurodegenerative diseases and to develop effective therapies.

31 May 2022