Topic: Research Progress of Animal Models of Neurological Disorders: New Pathogenic Insights and Therapies

Neurological disorders encompass a spectrum of conditions affecting the central and peripheral nervous system, ranging from Alzheimer's disease, Parkinson's disease, and Huntington’s disease to Amyotrophic Lateral Sclerosis, epilepsy, stroke, brain tumors, and other neurological disorders. These disorders, impacting hundreds of millions of people worldwide, currently lack definitive cures, posing significant threats to human health. Animal models play a crucial role in studying these disorders and developing effective treatments. Rodent models, extensively utilized in modeling these diseases, have provided invaluable insights into their underlying mechanisms and pathogenesis. In recent years, advancements in gene editing technologies such as CRISPR/Cas9 have opened avenues for gene modification across various species. Consequently, large animal models have been employed in the study of neurological disorders, offering new tools and perspectives for understanding these diseases.

This Special Issue will summarize and present the latest research progress on the pathological mechanisms observed in animal models of neurological diseases, along with emerging therapeutic targets. We aim to provide a platform for global neuroscientists to share their exemplary research and exchange inspiring ideas. We welcome a range of contributions, including original research papers, reviews, perspectives, and views & comments.

We encourage submissions exploring animal models, pathogenic mechanisms and therapeutic strategies related to neurological disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic Lateral Sclerosis, Autism, traumatic brain injury, and stroke. Topics of interest include but are not limited to rodent models; studies involving large animal models such as pigs, dogs, and monkeys for investigating these diseases are also highly welcomed.

30 Jun 2024