Hot Keywords
bifidobacteria gut microbiota microbiome probiotics bacteriophage phages antibiotics microbial infant gut microbial ecology intestinal microbiome host-microbe interactions intestinal fungi microbial ecosystems metagenomics microbial DNA sequencing bifidobacterium genomic irritable bowel syndrome

Topic: Carbohydrate Active Enzymes from Gut Microbes and Their Activity on Dietary and Host Glycans

A special issue of Microbiome Research Reports

ISSN 2771-5965 (Online)

Submission deadline: 31 Mar 2023

Guest Editor(s)

  • Dr. Jose Munoz-Munoz
    Department of Applied Sciences, University of Northumbria, Newcastle Upon Tyne, United Kingdom.

    Website | E-mail

  • Prof. Gary Black
    Department of Applied Sciences, University of Northumbria, Newcastle Upon Tyne, United Kingdom.

    Website | E-mail

Special Issue Introduction

Human gut microbiota encoded many genes for carbohydrate metabolism. In fact, we rely on those microorganisms to fully metabolize dietary and host glycans because we lack the enzymes required to degrade those glycans. In return, the bacteria ecosystem obtains the carbon source needed for its growth. Because of the diverse range and type of polysaccharides in the human diet and hosts, they represent an excellent source to find new activities and expand our knowledge of these enzymes with potential biotechnological applications. Depending on the activity, carbohydrate-active enzymes or CAZYmes are classified into glycosyl transferases (GT) for the synthesis of oligo and polysaccharides, glycoside hydrolases (GH) for the breakdown of glycans with the help of water, polysaccharide lyases (PL) if this degradation is in the absence of water, carbohydrate esterases (CE) if the linkage broken is an ester group, and auxiliary activities (AA) which are enzymes helping others to act. These CAZYmes are classified into different families according to the aminoacidic homology, catalytic fold and mechanism in the CAZY database. So far, according to the enzymatic activity, this database has been classified as more than 170 GHs, 100 GTs, 40 PLs, 20 CEs, and 17 AAs. However, the field is rapidly expanding, with numerous new families discovered every year.

The aim of this special issue is to highlight innovative and emerging new enzymes with novel mechanisms from gut microbes that act on dietary or host glycans as substrates. In addition, we would like to discuss novel families and activities within existing ones that recently have been established in the field.

We welcome original or review manuscripts, perspectives, opinions, and commentaries on different aspects of this special issue, including but not limited to:

Innovative approaches to discover and study CAZYmes:
● OMICs to discover new enzymes/activities;
● Emergent CAZYmes families;
● Characterization of new and existing CAZYmes;
● Structural Biology of CAZYmes;
● Enzymatic synergy for complex glycan degradation.

Innovative approaches to engineer/improve CAZYmes:
● Protein engineering of CAZYmes;
● Directed evolution;
● Catalytic mechanism.

Submission Deadline

31 Mar 2023

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 31 Mar 2023
Contacts: Haidi Ding, Journal Manager,
Fiona Chen, Assistant Editor,

Published Articles

© 2016-2023 OAE Publishing Inc., except certain content provided by third parties