fig3

Figure 3. Management of pregnant patients with sickle cell disease based on a modified DHTR risk score. The modified risk score for DHTR combines the risk score of Narbey et al.^[90] with the risk of alloimmunization in patients who have received fewer than 20 units of RBCs, as described by Floch et al.^[91]. Notably, the risk of DHTR was underestimated for patients with a history of DHTR in the study by Narbey et al.^[81,90]. ACS: Acute chest syndrome; DHTR: delayed hemolytic transfusion reaction; HU: hydroxyurea; IUGR: intrauterine growth restriction; PrE: preeclampsia; RBC: red blood cells; SCD: sickle cell disease; VOC: vaso-occlusive crisis; WG: weeks of gestation.