fig3

The necessity for skeletal muscle contractile assays to assess treatment efficacy in DMD

Figure 3. In vivo contractile responses of mouse plantar flexors. (A) Torque contractile profiles at individual electrical stimulation frequencies. Note that the response to a single stimulation (the twitch) is presented separately; (B) Torque-Frequency relationship, showing the maximum torque at each electrical stimulation frequency; (C) Torque-Velocity relationship, depicting normalized torque (each torque value divided by the mouse’s body mass) at specific shortening velocities (in degrees per second); (D) Normalized Power derived from the torque-velocity relationship. Power is calculated as the product of force and the velocity, expressed in milliwatts/gram body mass. Data from wild-type (WT) and mdx mice aged 33 weeks (for in vivo methods, see Hamm et al., 2023[43]).

Rare Disease and Orphan Drugs Journal
ISSN 2771-2893 (Online)
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