REFERENCES
1. Zhou L, DeMarco KD, Murphy KC, et al. p21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy. Cancer Discov. 2026;16:571-91.
2. Dong Z, Luo Y, Yuan Z, Tian Y, Jin T, Xu F. Cellular senescence and SASP in tumor progression and therapeutic opportunities. Mol Cancer. 2024;23:181.
3. Siddique A, Simonsick EM, Gallicchio L. Functional decline among older cancer survivors in the Baltimore longitudinal study of aging. J Am Geriatr Soc. 2021;69:3124-33.
4. Han X, Ogongo MK, Tian F, et al. Cancer history and accelerated aging: findings from a nationally representative sample in the US. Cancer Causes Control. 2025;36:379-88.
5. Hesterberg RS, Davis JT, Handoo KJ, et al. Lymphoma accelerates T cell and tissue aging. Cancer Cell. 2025;43:1917-1936.e8.
6. Liu L, Wang Q, Chen M, et al. Cancer-cell-secreted DDAH1 induces TGF-β1/Smad3 signaling pathway to promote fibrosis and aging in lung. Nat Aging. 2026;6:143-61.
7. Hoshino A, Costa-Silva B, Shen TL, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329-35.
8. Meguro S, Johmura Y, Wang TW, et al. Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion. Nat Aging. 2024;4:1582-97.
9. Li H, Zhao R, Wan L, et al. Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging. Nat Aging. 2026;6:1042-63.
10. Acosta JC, Banito A, Wuestefeld T, et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 2013;15:978-90.





