REFERENCES

1. Guo J, Liang R, Chung A, et al. The origin of hepatocellular carcinoma depends on metabolic zonation. Science. 2026;391:eadv7129.

2. Barrows KM, Porat-Shliom N. Hot zones for liver cancer: metabolic zonation, ferroptosis, and the origins of HCC. Cancer Res. 2026;86:1347-50.

3. Zhu M, Lu T, Jia Y, et al. Somatic mutations increase hepatic clonal fitness and regeneration in chronic liver disease. Cell. 2019;177:608-21.e12.

4. Brunner SF, Roberts ND, Wylie LA, et al. Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature. 2019;574:538-42.

5. Ng SWK, Rouhani FJ, Brunner SF, et al. Convergent somatic mutations in metabolism genes in chronic liver disease. Nature. 2021;598:473-8.

6. Giera S, Braeuning A, Köhle C, et al. Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver. Toxicol Sci. 2010;115:22-33.

7. Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575:693-8.

8. Raven A, Gilroy K, Jin H, et al. Hepatic zonation determines tumorigenic potential of mutant β-catenin. Nature. 2026;649:739-48.

9. Carlessi R, Denisenko E, Boslem E, et al. Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential. Cell Genom. 2023;3:100301.

10. Watson BR, Paul B, Rahman RU, et al. Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution. Nat Commun. 2025;16:319.

11. Li Z, Luo G, Gan C, et al. Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease. Nat Genet. 2025;57:3112-25.

12. Sugimoto A, Saito Y, Wang G, et al. Hepatic stellate cells control liver zonation, size and functions via R-spondin 3. Nature. 2025;640:752-61.

13. Yakubovsky O, Bahar Halpern K, Shir S, et al. A spatial atlas of the healthy human liver from live donors. Nature. 2026;653:1148-57.

14. Weiss CAM, Brown LA, Miranda L, et al. Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture. Nat Metab. 2026;8:741-56.

Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
Follow Us

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/